Flumox Mechanism of Action


Zifam Pinnacle


Full Prescribing Info
Pharmacology: Pharmacokinetics: Flumox offers an advantage due to similar pharmacokinetic profile of both the antibiotics. Amoxicillin is rapidly absorbed upon oral administration and diffuses into most body fluids and tissues, except brain where it crosses the barrier only when meninges are inflamed. Amoxicillin is 20% serum bound and 56-65% is excreted unchanged in urine within 6 hrs. Flucloxacillin is almost completely absorbed upon oral administration and has similar distribution as seen with amoxicillin. Flucloxacillin is highly serum protein-bound ≥95.2%, however, rapidly excreted unchanged in urine via glomerular filtration. The combination in Flumox achieves therapeutic concentrations at 50 min to 1 hr of oral administration with peak at 2 hrs and half-life at 1.4-2 hrs. Peak levels after IM or IV injection are quickly achieved within 30 min.
Microbiology: Spectrum of Activity: Flumox offers extended spectrum of activity, greater than either of the antibiotics and superior activity against few important pathogens.
Gram-Positive: α- and β-Hemolytic Streptococci, Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus both penicillin-sensitive and penicillinase-producing pathogens, Diplococcus pneumoniae, Bacillus anthracis and most strains of enterococci and Clostridia.
Gram-Negative: Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Neisseria catarrhalis, Escherichia coli, Proteus mirabilis, Bacteroides fenduliformis, Salmonella and Shigella.
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