Full Prescribing Info
Fugacar inhibits the formation of the worm microtubules and causes the worms' glucose depletion.
Pharmacology: Pharmacokinetics: Following administration of 100 mg twice daily for 3 consecutive days, plasma levels of Fugacar and its primary metabolite, the 2-amine, do not exceed 0.03 mcg/mL, respectively. All metabolites are devoid of anthelmintic activity. In man, approximately 2% of administered Fugacar is excreted in urine and remainder in the faeces as unchanged drug or a primary metabolite.
Microbiology: With a potent anthelmintic activity against nematodes. Fugacar is effective against Enterobius vermicularis (pinworm), threadworm, Ascaris lumbricoides (large roundworm), Ancylostoma duodenale (hookworm) and Trichuris trichiura (whipworm).
Treatment of enterobiasis, ascariasis, trichuriasis, ancylostomiasis in single or mixed infections.
Dosage/Direction for Use
The same dosage schedule applies to children and adults. The tablet may be chewed, swallowed or crushed, and mixed with food.
Ascariasis, Enterobiasis, Ancylostomiasis, Trichuriasis: 500-mg single dose.
In the event of accidental overdosage, gastrointestinal complaints lasting up to a few hours may occur. Vomiting and purging should be induced.
Fugacar should not be administered in pregnant women during the first 3 months of pregnancy and patients suffering from liver disease.
Special Precautions
Carcinogenicity & Mutagenicity: In carcinogenicity tests of Fugacar in mice and rats, no carcinogenic effects were seen at doses as high as 40 mg/kg given daily for >2 years. Dominant lethal mutation tests in mice showed no mutagenicity at single doses as high as 640 mg/kg. Neither the spermatocyte test, the F1 translocation test, nor the Ames test indicated mutagenic properties.
Use in children: Mebendazole has not been extensively studied in children <2 years; therefore, in the treatment of children <2 years the relative benefit/risk should be considered.
Use In Pregnancy & Lactation
Since the safety of Fugacar during pregnancy has not been established, the drug should not be administered to pregnant women during the first 3 months of pregnancy.
Adverse Reactions
Transient symptoms of abdominal pain and diarrhea have occurred in case of massive infection and expulsion of worms.
MIMS Class
ATC Classification
P02CA01 - mebendazole ; Belongs to the class of benzimidazole derivative agents. Used as antinematodal.
Chewable tab 500 mg x 10 x 1's.
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