Hydrogen peroxide


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : Mouth/Throat Oral hygiene; Acute stomatitis As 1.5% soln: Gargle or rinse 10 mL up to 4 times/day. Topical Wound cleansing As ≤6% soln or as 1-1.5% gel: Apply 2-3 times/day.
Dosage Details
Mouth/Throat
Acute stomatitis, Oral hygiene
Adult: As 1.5% soln: Gargle or rinse thoroughly 10 mL up to 4 times daily. Do not swallow.
Child: ≥12 yr Gargle or rinse thoroughly 10 mL 3 times daily. Do not swallow.

Topical/Cutaneous
Wound cleansing
Adult: As ≤6% soln or as 1-1.5% cream/gel: Apply 2-3 times daily.
Incompatibility
Incompatible w/ products containing iodine or potassium permanganates, and other stronger oxidising agents.
Special Precautions
Not intended for use in closed body cavities and surgical wounds, deep wounds, for surgical equipment, and as enema.
Adverse Reactions
Significant: Burns on skin and mucous membranes (w/ white eschar), pain. Blistering, erythema, focal epidermal, necrosis, and purpura (concentrated soln). Hypertrophy of tongue papillae, mouth ulcerations, mucosal erythema, sloughing, inflammation or hyperplasia (prolonged oral use).
Resp: Irritation of pulmonary membranes, coughing, dyspnoea.
Patient Counseling Information
Avoid contact w/ eyes and healthy normal skin.
Overdosage
Symptoms: Sore throat, GI disturbance and vomiting, distention of stomach and internal bleeding. Management: Symptomatic and supportive treatment.
Action
Description: Hydrogen peroxide exerts its weak antibacterial action by releasing nascent oxygen upon contact w/ tissues containing the enzyme catalase. Furthermore, the mechanical effect of the effervescence loosens tissue debris and pus thus reducing the amount of bacteria in wounds.
Storage
Store below 25°C. Protect from light.
ATC Classification
D08AX01 - hydrogen peroxide ; Belongs to the class of other antiseptics and disinfectants. Used in the treatment of dermatological diseases.
A01AB02 - hydrogen peroxide ; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth.
References
Anon. Hydrogen Peroxide. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 15/06/2017.

Buckingham R (ed). Hydrogen Peroxide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 15/06/2017.

Crystacide Cream 1% (Reig Jofre UK Limited). MHRA. https://products.mhra.gov.uk/. Accessed 15/06/2017.

Joint Formulary Committee. Hydrogen Peroxide. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 15/06/2017.

McEvoy GK, Snow EK, Miller J et al (eds). Hydrogen Peroxide (EENT). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 15/06/2017.

Peroxyl Mouth Sore Mild Mint (Colgate Oral Pharmaceuticals, Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 15/06/2017.

Disclaimer: This information is independently developed by MIMS based on Hydrogen peroxide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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