Indigo carmine


Concise Prescribing Info
Indications/Uses
As a marker dye in urological procedures.
Dosage/Direction for Use
Adult : IV/IM 40 mg preferably via slow IV inj. May also be given via IM inj.
Dosage Details
Parenteral
Marker dye in urological procedures
Adult: 40 mg preferably via slow IV inj. May also be given via IM inj.
Contraindications
Uncontrolled heart failure, history of allergic reactions, haemodynamic instability.
Special Precautions
Patient with heart rate and conduction disorders, hypertension, coronary disorders. Pregnancy and lactation.
Adverse Reactions
Significant: Idiosyncratic reactions (e.g. rash, pruritus bronchoconstriction), paradoxical pressor effects.
Cardiac disorders: Bradycardia.
Gastrointestinal disorders: Nausea, vomiting.
Skin and subcutaneous tissue disorders: Skin discoloration (large doses in children and underweight patients).
Vascular disorders: Hypertension.
IM/IV/Parenteral: C
Overdosage
Symptoms: Hypertensive crisis and severe bradycardia. Management: May administer peripheral vasodilators.
Lab Interference
May interfere with colorimetric methods of urinalysis.
Action
Description: Indigo carmine is a marker dye which retains its blue colour during passage through the body. It is used in the test of renal function.arker 
Pharmacokinetics:
Excretion: Via urine. Elimination half-life: 4-5 minutes (IV).
Chemical Structure

Chemical Structure Image
Indigo carmine

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 2723854, Indigo carmine. https://pubchem.ncbi.nlm.nih.gov/compound/Indigo-carmine. Accessed Sept. 25, 2020.

Storage
Store between 15-30°C. Protect from light.
ATC Classification
V04CH02 - indigo carmine ; Belongs to the class of diagnostic agents used to test for renal function.
References
Anon. Indigotindisulfonate Sodium. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 16/07/2020.

Anon. Indigotinedisulfonate. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 16/07/2020.

Buckingham R (ed). Indigo Carmine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 16/07/2020.

Indigo Carmine 40 mg/5 mL Solution for Injection (SERB S.A.). MHRA. https://products.mhra.gov.uk/. Accessed 16/07/2020.

Indigo Carmine Injection, Solution (American Regent, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 16/07/2020.

Disclaimer: This information is independently developed by MIMS based on Indigo carmine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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