Interferon alfa-2A


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : SC Renal cell carcinoma In an escalating dose of 3 million u 3 times/wk for 1 wk, then 9 million u 3 times/wk for 1 wk, then 18 million u 3 times/wk thereafter for 3-12 mth. Chronic hepatitis B 2.5-5 million u/m2 3 times/wk for 4-6 mth. Chronic hepatitis C W/ ribavirin: 3-4.5 million u 3 times/wk for 6 mth. Monotherapy: 3 million u 3 times/wk for 12 mth. Hairy cell leukaemia 3 million u/day for 16-24 wk. Maintenance: 3 million u 3 times/wk, up to 24 wk. AIDS related Kaposi's sarcoma In an escalating dose of 3 million u/day for 3 days, 9 million u/day for 3 days, 18 million u/day for 3 days, and 36 million u/day (if tolerated) on days 10-84. thereafter max tolerated dose (up to 36 million u) 3 times/wk. Chronic myeloid leukaemia In an escalating dose of 3 million u/day for 3 days, 6 million u/day for 3 days, and 9 million u/day thereafter. For responders after 12 wk: Continue treatment until haematological response is complete or up to 18 mth. Follicular lymphoma As adjunct to chemotherapy: 6 million u/ m2/day on days 22-26 of each 28-day cycle. Cutaneous T-cell lymphoma In an escalating dose of 3 million u/day for 3 days, then 9 million u/day for 3 days, and then 18 million u/day to complete 12 wk of treatment. Thereafter, max tolerated dose (up to 18 million u) 3 times/wk for at least 12 mth in responders. Melanoma 3 million u 3 times/wk for 18 mth. Start treatment no later than 6 wk after surgery.
Dosage Details
Subcutaneous
Hairy cell leukaemia
Adult: 3 million units daily for 16-24 wk. Maintenance: 3 million units 3 times/wk. May continue treatment for up to 24 wk.

Subcutaneous
AIDS-related Kaposi's sarcoma
Adult: In an escalating dose of 3 million units daily for 3 days, 9 million units daily for 3 days, 18 million units daily for 3 days, and 36 million units daily, if tolerated, on days 10-84. thereafter the max tolerated dose (up to 36 million units) may be given 3 times wkly.

Subcutaneous
Chronic hepatitis C
Adult: 3-4.5 million units 3 times wkly for 6 mth when used with ribavirin. As monotherapy: Initial: 3-6 million units 3 times wkly for 6 mth followed by 3 million units 3 times wkly for an additional 6 mth, or 3 million units 3 times wkly for 12 mth.

Subcutaneous
Renal cell carcinoma
Adult: As an adjunct to cytotoxic chemotherapy: In an escalating dose of 3 million units 3 times wkly for 1 wk, then 9 million units 3 times wkly for 1 wk, then 18 million units 3 times wkly thereafter for 3-12 mth.

Subcutaneous
Cutaneous T-cell lymphoma
Adult: In an escalating dose of 3 million units daily for 3 days, then 9 million units daily for 3 days, and then 18 million units daily to complete 12 wk of treatment. Thereafter, the max tolerated dose (up to 18 million units) is given 3 times wkly for at least 12 mth in responders.

Subcutaneous
Chronic myeloid leukaemia
Adult: In an escalating dose of 3 million units daily for 3 days, 6 million units daily for 3 days, and 9 million units daily thereafter. For responders after 12 wk: Continue treatment until a complete haematological response is achieved or for a max of 18 mth; for those who achieve a complete haematological response: Continue on 9 million units daily (at least 9 million units 3 times wkly) in order to achieve a cytogenetic response.

Subcutaneous
Chronic hepatitis B
Adult: 2.5-5 million units/m2 3 times/wk for 4-6 mth.

Subcutaneous
Follicular lymphoma
Adult: As an adjunct to chemotherapy: 6 million units/ m2 daily on days 22-26 of each 28-day chemotherapy cycle.

Subcutaneous
Melanoma
Adult: 3 million units 3 times/wk for 18 mth. Start treatment no later than 6 wk after surgery.
Contraindications
Hypersensitivity. Autoimmune hepatitis, hepatic decompensation.
Special Precautions
History of depression (monitor for signs). Perform regular neuropsychiatric monitoring. Seizure disorders and/or compromised CNS function. Preexisting or any history of cardiac disease. Monitor CBC prior to and during therapy. Myelosuppression or concurrent use of myelosuppressive drugs. Hypothyroidism, hyperthyroidism, DM. Perform ophthalmological exam on patients with preexisting ophthalmologic disorders (e.g. diabetic or hypertensive retinopathy). Monitor patients with impaired renal function. Creatinine clearance <50 ml/min. May impair ability to drive or operate machinery. Pregnancy and lactation.
Adverse Reactions
Depressive illness, suicidal behaviour, irritability, insomnia, anxiety. Flu-like symptoms. Headache, dizziness, paraesthesia, confusion, impaired concentration, alteration in taste or smell. GI disturbances. Dryness of oropharynx, epistaxis, rhinitis, arrhythmia, sinusitis. Inj site reaction, alopecia, rash, dry skin or pruritus. Conjunctivitis, menstrual irregularity, visual disturbances. Coughing, dyspnoea. Myalgia, joint or bone pain, arthritis or polyarthritis. Bone marrow depression.
Potentially Fatal: Marked increase in triglyceride levels, GI haemorrhage, severe infections, pulmonary infiltrates or pulmonary function impairment.
Overdosage
Symptoms may include profound lethargy, fatigue, prostration and coma.
Drug Interactions
Reduces clearance of theophylline. Enhanced myelosuppression with other myelosuppressive drugs (e.g. zidovudine). Drugs metabolised by CYP450 pathway (monitor for changes in pharmacologic or adverse effects of concomitant drug). Increased risk of toxicity of centrally acting drugs. Increased risk of renal failure with interleukin-2.
Action
Description: Interferon alfa-2a has antiviral, antitumour and immunomodulatory activity. It inhibits replication of a wide range of RNA and DNA viruses. It also exerts antiproliferative effects on normal and malignant cells. Interferon alfa-2a suppresses antibody formation through an effect on B-lymphocytes and inhibits onset of delayed hypersensitivity.
Pharmacokinetics:
Absorption: >80% is absorbed (IM); peak plasma concentrations within 4-8 hr (IM).
Excretion: Via urine (negligible amounts); 3.7-8.5 hr (elimination half-life).
Storage
Store in a refrigerator at 2-8°C (36-46°F).
Disclaimer: This information is independently developed by MIMS based on Interferon alfa-2A from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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