Invokana

Invokana

canagliflozin

Manufacturer:

Janssen-Cilag

Distributor:

DKSH
Concise Prescribing Info
Contents
Canagliflozin
Indications/Uses
Adjunct to diet & exercise as monotherapy or in combination w/ metformin, insulin, DPP-4 inhibitor (eg, sitagliptin, saxagliptin, or linagliptin), sulphonylurea (eg, glimepiride or glipizide), or pioglitazone in the treatment of type 2 diabetes.
Dosage/Direction for Use
Initially 100 mg tab each day, may be increased to 300 mg if necessary. Patient w/ kidney problem Max: 100 mg.
Administration
May be taken with or without food: Preferably taken before the 1st meal of the day.
Contraindications
Special Precautions
Not to be used for type 1 diabetes & diabetic ketoacidosis. Risk of lower limb (mainly toes) amputation. Present or history of serious heart disease or stroke; hypotension. Concomitant use w/ antihypertensives & diuretics. Regularly check feet for wounds, discolouration, pain/tenderness & ensure foot care & adequate hydration. Test for kidney function prior to & during treatment. False positive result for urine glucose. Patients w/ lactose intolerance. Patients w/ severe kidney/liver problems or those on dialysis. Increased risk of hypoglycaemia w/ other antidiabetics. Dizziness or lightheadedness may occur which may affect the ability to drive, cycle, or use tools or machines. Not to be used during pregnancy & lactation. Not recommended for childn & adolescents <18 yr.
Adverse Reactions
Hypoglycaemia; vag yeast infection. Rash/redness of the penis or foreskin (yeast infection); UTI; changes in urination (eg, frequent or large amounts of urination, urgent need to urinate & at night); constipation; feeling thirsty; nausea; possible changes in blood cholesterol levels & increases in haematocrit.
Drug Interactions
Hypoglycaemia w/ other antidiabetics eg, insulin or sulphonylurea (eg, glimepiride or glipizide). May lower BP w/ antihypertensives eg, diuretics. St. John's wort; carbamazepine, phenytoin, or phenobarb; efavirenz or ritonavir; rifampicin; cholestyramine; digoxin or digitoxin; dabigatran.
MIMS Class
Antidiabetic Agents
ATC Classification
A10BK02 - canagliflozin ; Belongs to the class of sodium-glucose co-transporter 2 (SGLT2) inhibitors. Used in the treatment of diabetes.
Presentation/Packing
Form
Invokana FC tab 100 mg
Packing/Price
30's
Form
Invokana FC tab 300 mg
Packing/Price
30's
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