Isepamicin


Concise Prescribing Info
Indications/Uses
Susceptible infections.
Dosage/Direction for Use
Adult : IV/IM Up to 15 mg/kg/day.
Dosage Details
Parenteral
Susceptible infections
Adult: Up to 15 mg/kg daily by IM injection or IV infusion in 2 divided doses. Adjust dose based on serum isepamicin conc monitoring. Total dose should not exceed 1.5 g/day.
Contraindications
Pregnancy; hypersensitivity.
Special Precautions
Myasthenia gravis; regular assessment of auditory and renal function is necessary in patients with additional risk factors. Cystic fibrosis, obesity.
Adverse Reactions
Ototoxicity; nephrotoxicity; electrolyte disturbances; respiratory depression; muscular paralysis; cross-sensitivity with other aminoglycosides.
Drug Interactions
Other nephrotoxic drugs eg, vancomycin, cephalosphorins, ciclosporin, cisplatin and fludarabine; potentially ototoxic drugs eg, ethacrynic acid, furosemide; neuromuscular-blocking agents; general anesthetics; opioids; β-lactams; dimenhydrinate.
Action
Description: Isepamicin is a semisynthetic aminoglycoside which inhibits protein synthesis by binding to 30s and 50s ribosomal subunits in susceptible bacteria.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Isepamicin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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