InductionInitiate at a conc of 0.5%. Surgical anaesth is usually produced in 7-10 min w/ conc of 1.5-3%. Maintenance1-2.5% isoflurane in a 30% O2/70% nitrous oxide mixture. Additional 0.5-1% isoflurane may be required w/ lower nitrous oxide levels, or given w/ O2 alone, or w/ air/O2 mixtures. Recovery Reduce to 0.5% at the start of closing of operation wound, then to 0% at the end of surgery. Ventilate patient with O2 100% until complete recovery.
Hypersensitivity to isoflurane & other halogenated agents. Malignant hyperthermia. Patients who have developed icterus &/or fever of unknown origin, hepatic impairment or eosinophilia after administration.
Increased intracranial pressure. Avoid repeated anaesth w/in a short period of time. Perform direct measurement of carboxyhaemoglobin during closed-circuit anaesth. Preexisting liver disease & coronary artery disease (subendocardial, ischaemia). Latent or overt neuromuscular disease particularly Duchenne muscular dystrophy. Prompt & vigorous treatment for hyperkalemia & arrhythmias is recommended. May impair ability to drive & operate machinery. Pregnancy & lactation.
Potentiate effects of muscle relaxants. May cause arrhythmias w/ adrenaline & other β-sympathomimetic drugs eg amphetamines. May cause hypotension w/ Ca antagonists. Enhanced effects of general anaesth w/ MAOIs & opioid analgesics. Reduced effects w/ β-blockers. Increased risk of hepatotoxicity w/ INH.
Manage Account
Change Password
Sign Out
