Ixekizumab is used to treat plaque psoriasis (a type of skin disease that is caused by itchy patches of thick, red skin and silvery scales).
This medicine may also be used to treat psoriatic arthritis (joint pain and swelling with inflammation of the skin).
Your doctor or nurse will administer the injection for you. If you or your caregiver had been given the proper training on the preparation and injection techniques of this medicine, you or your caregiver may do the administration.
Use this medicine exactly as directly by your doctor or according to the instructions on the label. Do not administer more or less than instructed by your doctor.
Ixekizumab is to be injected subcutaneously (into the fatty layer under the skin, usually in the thigh, upper arm or abdomen area).
Remember to rotate the injection sites. Do not inject into the same area all the time. New injection sites should be at least 1.5 inches away from the previous injection site. Do not inject near the navel (belly button).
This medicine is available as a single-use pre-filled pen or syringe. Make sure you know how to use the specific device you have been given. If you have problems or do not understand the instructions, ask your doctor or pharmacist.
To administer this medicine using an injection pen:
- Prepare the injection pen as instructed by your doctor or nurse.
- Attach the needle to the injection pen. Ensure that the needle is screwed on securely.
- Dial the correct dose.
- Swab the injection site area with alcohol.
- Hold the injection pen with your thumb over the injection button.
- Press the injection pen against your body using the subcutaneous injection method.
- Use your thumb to push the injection button until it stops. Continue to hold the injection button in that position while slowly counting to 5-10 seconds to get a full dose.
- Withdraw the injection pen from your body.
- Remove the needle from the pen. Never store the injection pen with the needle attached.
- Reset your pen as instructed by your healthcare provider.
- Use a new needle in every administration of Ixekizumab.
To administer this medicine using an injection syringe:
- Prepare the injection syringe as instructed by your doctor or nurse.
- Remove the prepared syringe and needle from the vial and hold the injection syringe with your thumb over the plunger.
- Insert the needle against your body using the subcutaneous injection method.
- Gently press the plunger all the way down until the syringe is empty.
- Slowly let go of the skin and gently pull the needle out of the skin. Do not recap the needle.
- Dispose your used needles and syringes according to your doctor or pharmacist’s instructions. Do not throw away in household trash.
The dose of this medicine will be decided by your doctor. Your doctor will advise you on the dose and course of the treatment depending on the type and severity of your condition.
This medicine must be administered regularly for it to be effective. Continue using Ixekizumab even when you feel better. Do not stop using it unless instructed by the doctor.
Ensure that you keep all appointments with your doctor so that you do not miss any dose. Your doctor also needs to regularly monitor your response to Ixekizumab.
If you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.
If you or a caregiver had been trained to administer this medicine, inject the missed dose as soon as you remember and return to your normal dosing schedule.
DO NOT double a dose under any circumstances.
If you often forget to administer your medicine, let your doctor and pharmacist know.
Do not use Ixekizumab if you ever had an allergic reaction (e.g. rashes, breathlessness, swollen eyes) to similar medicines.
Alert your doctor if you have an active infection (e.g. TB) as Ixekizumab may not be suitable for you.
Do not use this medicine if you are pregnant. If you become pregnant while on Ixekizumab therapy, alert your doctor immediately. This medicine may cause harm to your unborn child.
It is important that you do not get pregnant while using this medicine. You must use proven birth control methods during Ixekizumab therapy and at least 10 weeks after stopping the treatment. Birth control medicines containing hormones may not be effective. You may wish to discuss other reliable methods of birth control with your doctor.
Inform your doctor if you have the following conditions:
- currently have or history of a serious infection or repeated infection
- bowel disease, e.g. Crohn’s disease (long-term inflammatory disease of the bowel), ulcerative colitis (inflammation of the large intestines)
Let your doctor know if you are breastfeeding.
Inform your doctor if you have been recently vaccinated. Do not receive any vaccinations without first asking your doctor.
Why is it important to keep my appointments with the doctor?
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
Screening for infections such as TB may be needed to check the appropriateness of Ixekizumab therapy.
Regular monitoring of signs and symptoms of infections or bowel inflammation may be needed while you are being treated with this medicine.
Ixekizumab cause any of the following side effects: injection site reactions (e.g. skin redness, pain), upper airway infections with symptoms (runny nose, sore throat), tinea (fungal) infections (e.g. athlete’s foot), oral candidiasis (oral thrush), conjunctivitis (redness and inflammation of the membranes covering the white part of eyes).
Other side effects include any of the following: flu-like symptoms, rash, nausea, mucocutaneous herpes simplex (cold sores of mouth, skin and mucous membranes).
If you develop rashes, breathlessness, swollen mouth or eyes, stop taking Ixekizumab and inform your doctor immediately. These could be signs of an allergic reaction.
This medicine may cause the level of your white blood cells and platelets to drop.
White blood cells help your body to fight infections. A fall in the level of your white blood cells may put you at higher risk for infections, such as coughs, colds and flu, which may lead to more serious infections. Avoid crowded places and people who are sick. Inform your doctor if you have a fever, or a cough or flu that does not go away.
Platelets help your blood to clot when there is a cut in the skin. A fall in the level of your platelets may put you at risk of bleeding more than usual. Do not take part in activities where you may fall or get injured, such as contact sports. Inform your doctor if you get any unusual bruising (large bruises or several bruises, especially if the bruises appeared on their own) or bleeding that takes a long time to stop (for example, too much bleeding when you floss or brush your teeth).
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Avoid live vaccine vaccinations during treatment with Ixekizumab.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
Store in a refrigerator, between 2-8°C. May store below 30°C for up to 5 days only.
Do not allow to freeze. If frozen, this medicine will become ineffective and should not be used.
Protect from light by keeping it inside the carton.
Medicines must not be used past the expiry date.
This medicine should not be thrown in the household waste. Ask your doctor or pharmacist how to properly dispose this medicine.