Ketoprofen - rectal

Patient Medicine Information
Why do I need this medicine?
Ketoprofen helps relieve pain and reduce inflammation associated with conditions affecting joints or muscles (e.g. muscle strains or sprains, sport injuries).
How do I use this medicine?
Use this medicine exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

Ketoprofen suppository is to be inserted into the rectum. Do not eat, chew or swallow it. Do not use it in any other way.

Try to go to the toilet before you insert the suppository.

Follow these steps:
  1. Wash your hands thoroughly.
  2. Remove the suppository from the foil wrapper.
  3. If you are right-handed, lie on your left side and pull your right knee up to your chest.
  4. Gently insert the suppository with the pointed end first into your rectum. Gently push the suppository as far as it would go.
  5. Remain lying in this position for 10 -15 minutes to allow the suppository to melt. If you feel that the suppository is slipping out, press your buttocks together. The suppository must remain in the rectum so that the medicine can be absorbed.
What should I do if I have forgotten to use this medicine?
Use the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Do not use this medicine if you ever had an allergic reaction (rashes, breathlessness, swollen eyes) to similar medicines such as ibuprofen, mefenamic acid and aspirin.

Alert your doctor if you have the following conditions:
  • asthma related in aspirin intake
  • bleeding
  • severe heart disease
  • haemorrhoids or proctitis (stomach or anal pain, anal bleeding, discharge from anus)
  • severe liver disease
  • severe kidney disease
  • history of stomach ulcers
as Ketoprofen may not be suitable for you.

Do not use Ketoprofen if you are on 3rd trimester of pregnancy. This medicine may cause harm to your unborn child.

This medicine should not be used to treat pain before and after coronary artery bypass graft surgery (procedure to improve and restore the blood flow in the heart).
What should I take note of while using this medicine?
Inform your doctor if you have the following conditions:
  • heart disease or high blood pressure
  • swelling of ankles, feet or hand
  • bowel disease e.g. ulcerative colitis, Crohn’s disease
  • mild to moderate kidney or liver disease
Let your doctor know if you are pregnant or breastfeeding.

Be sure to check with your doctor or pharmacist before giving Ketoprofen to an elderly person. Elderly people may be more sensitive to the side effects.
What side effects could I experience?
Ketoprofen may cause any of the following side effects: headache, stomach pain, constipation, diarrhoea, nausea, vomiting; anal burning, itching, pain and rarely, bleeding.

Some side effects may be serious, although they are not common. Alert your doctor quickly if you experience:
  • heart disease (pressure, tightness or pain in your chest or arms spreading to your neck, jaw or back; shortness of breath; sudden dizziness)
  • stroke (sudden weakness or numbness in face, arm or leg; speech difficulty, dizziness, loss of balance)
  • stomach bleeding (black stool, bright red blood in vomit, stomach cramps, shortness of breath)
  • liver disease (yellowing of the skin and whites of eyes; weight loss, loss of appetite, pain or tenderness around the liver area)
  • rashes with peeling of the skin or blistering of the lips, mouth or eyes accompanied by fever
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I use this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:
  • lithium (medicine for mood disorders)
  • methotrexate, ciclosporin, tacrolimus (medicines used in organ transplant or certain immune disorders)
  • NSAIDs (medicine for pain and inflammation) e.g. ibuprofen, indomethacin
  • blood-thinning medicines e.g. aspirin, heparin, warfarin
  • medicines for high blood pressure or heart disease e.g. captopril, digoxin
  • diuretic or “water pills” e.g. furosemide, hydrochlorothiazide
  • corticosteroids (anti-inflammatory medicines) e.g. prednisolone, dexamethasone
This list does not include all medicines that may interact with Ketoprofen.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on ketoprofen - rectal and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by
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