Ketoprofen - rectal

Patient Medicine Information
Why do I need this medicine?
Ketoprofen helps relieve pain and reduce inflammation associated with rheumatoid arthritis (inflammation in joints of fingers, wrist, feet, ankles) and osteoarthritis (joint pain and swelling due to bone damage or deterioration).
How do I use this medicine?
Use this medicine exactly as directed by your doctor or according to the instructions on the label. Do not use more or less than instructed by your doctor.

Ketoprofen suppository is to be inserted into the rectum. Do not eat, chew or swallow it. Do not use it in any other way. Try to go to the toilet before you insert the suppository.

To use the rectal suppository, follow these steps:
  1. Wash your hands thoroughly.
  2. Remove the suppository from the foil wrapper.
  3. If you are right-handed, lie on your left side and pull your right knee up to your chest.
  4. Gently insert the suppository with the pointed end first into your rectum. Gently push the suppository as far as it would go.
  5. Remain lying in this position for 10 -15 minutes to allow the suppository to melt. If you feel that the suppository is slipping out, press your buttocks together. The suppository must remain in the rectum so that the medicine can be absorbed.
  6. Wash your hands thoroughly after use.
What should I do if I have forgotten to use this medicine?
Use the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.
When should I not use this medicine?
Do not use this medicine if you ever had an allergic reaction (e.g. rashes, breathlessness, swollen eyes) to Ketoprofen or similar medicines such as ibuprofen, diclofenac or aspirin.

Alert your doctor if you have the following conditions:
  • history of asthma, rhinitis (inflammation of the inside lining of the nose caused by allergens), skin rash, or other allergic reactions after taking aspirin or similar painkillers
  • active stomach or intestinal ulcer, bleeding or perforation
  • history of stomach and/or intestinal bleeding, perforation, or ulceration related to NSAID therapy
  • history of haemorrhoids (swollen veins in the anus) or proctitis (inflammation of the lining of the rectum)
  • long-term indigestion
  • bleeding problems
  • severe heart failure (weakness and inability of the heart to pump blood)
  • severe kidney disease
  • severe liver disease
as this medicine may not be suitable for you.

Do not use Ketoprofen if you are in your 3rd trimester of pregnancy. If you become pregnant while being treated with this medicine, alert your doctor immediately. Ketoprofen may cause harm to your unborn child.

This medicine should not be used to treat pain in the setting of a coronary artery bypass graft surgery (procedure to improve and restore the blood flow in the heart).
What should I take note of while using this medicine?
Inform your doctor if you have the following conditions:
  • heart problems
  • high blood pressure
  • swelling of ankles, feet or hand
  • history of bowel disease e.g. ulcerative colitis (inflammation of the large intestines), Crohn's disease (long-term inflammatory disease of the digestive tract)
  • asthma
  • mild to moderate kidney disease
  • mild to moderate liver disease
Let your doctor know if you are in your 1st or 2nd trimester of pregnancy, or if you are breastfeeding.

Be sure to check with your doctor or pharmacist before giving Ketoprofen to the elderly. Elderly people may be more sensitive to the side effects.

If you are going to have an operation, including minor surgery and dental work, inform your doctor or dentist that you are using this medicine.
What side effects could I experience?
Ketoprofen may cause drowsiness, dizziness or blurred vision. If affected, do not drive or take part in any activity in which you need to be alert or need to see clearly.

Other side effects include any of the following: headache, stomach pain, constipation, diarrhoea, nausea, vomiting and local pain, burning sensation or itching at the application site.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • rashes, breathlessness, swelling of the face, eyes, or mouth
  • chest pain or tightness, fast or irregular heartbeat, unusual tiredness
  • sudden difficulty in speaking, loss of balance, weakness or numbness in the face, arms, or legs
  • pass out bloody or black as tar stools and vomiting blood or ground coffee-like material
  • yellowing of the skin or eyes, abdominal pain, dark coloured urine, swelling in the legs and ankles
  • unusual bleeding or bruising
  • rashes with peeling of the skin or blistering of the lips, mouth or eyes accompanied by fever
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I use this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:
  • other NSAIDs (medicines for pain and inflammation) e.g. aspirin, ibuprofen, diclofenac
  • blood-thinning medicines e.g. warfarin, heparin
  • water pills or medicines for water retention e.g. hydrochlorothiazide, furosemide
  • medicines for high blood pressure e.g. enalapril, losartan
  • medicines used in organ transplant or certain immune disorders e.g. ciclosporin, tacrolimus
  • lithium (medicine for mood disorders)
  • digoxin (medicine for heart disease)
  • methotrexate (medicine for cancer)
  • probenecid (medicine for gout or high uric acid level in the blood)
This list does not include all medicines that may interact with Ketoprofen.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on ketoprofen - rectal and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2023 MIMS. All rights reserved. Powered by
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