Ketorex Mechanism of Action





Full Prescribing Info
Pharmacology: Pharmacodynamics: Ketoconazole is a broad spectrum synthetic antifungal agent which impairs the synthesis of ergosterol, which is a vital component of fungal cell membranes. Ketoconazole works principally by inhibiting the enzyme cytochrome P450 14-alpha-demethylene (P45014DM).
Ketoconazole has a potent antimycotic action against dermatophytes and yeasts. Ketoconazole cream acts rapidly on the pruritus, which is commonly seen in dermatophyte and yeast infections. This symptomatic improvement often occurs before the first signs of healing are observed.
Pharmacokinetics: Plasma concentrations of ketoconazole were not detectable after topical administration of Cream in adults on the skin. In one study in infants with seborrhoeic dermatitis [n=19], where approximately 40 g of cream was applied daily on 40% of the body surface area, plasma levels of ketoconazole were detected in 5 infants, ranging from 32 to 133 ng/mL.
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