Ketorolac Trometamol Darya-Varia

Ketorolac Trometamol Darya-Varia

ketorolac

Manufacturer:

Darya-Varia

Distributor:

Royal Ruby
Concise Prescribing Info
Contents
Ketorolac trometamol
Indications/Uses
Short term management of moderately severe, acute pain following surgical procedures.
Dosage/Direction for Use
Initially 10 mg by IM or bolus IV inj followed by 10-30 mg every 4-6 hr. Non-elderly Max daily dose: 90 mg. Max duration: 2 days. Elderly >65 yr, renally impaired patients, patients <50 kg Max daily dose: 60 mg. Max duration: 2 days.
Contraindications
Hypersensitivity to ketorolac trometamol, aspirin or other NSAIDs. Active peptic ulcer, recent GI hemorrhage or perforation & history of PUD or GI bleeding. Haemostasis disorder. Suspected or confirmed cerebrovascular disease, haemorrhage diatheses or incomplete haemostasis, & those w/ high risk of bleeding. Neuraxial (epidural or intrathecal) administration. History of asthma. Complete or partial syndrome of nasal polyps, angioedema or bronchospasm. Concurrent treatment w/ other NSAIDs or probenecid; oxpentifylline or lithium salt. Severe renal dysfunction or those w/ high risk of renal failure. Not recommended during pregnancy, labour or delivery. Lactation. Childn <16 yr.
Special Precautions
Not recommended for use as pre-op medication. Discontinue if liver function test is abnormal after administration. Patients w/ history of GI tract disease; coagulation disorders (hemophilic) or on anticoagulant therapy; heart disease, acute renal failure, HTN; cardiac decompensation. Impaired hepatic function or history of liver disease.
Adverse Reactions
Ulcers, GI bleeding & perforation, post-op haemorrhage, acute renal failure, anaphylactic & anaphylactoid reactions, liver failure. Edema; HTN; pruritus, rash; nausea, dyspepsia, GI pain & fullness, diarrhea, constipation, flatulence, vomiting, stomatitis; purpura; cephalgia, drowsiness, dizziness, sweating; pain in inj site.
Drug Interactions
Side effect may be enhanced w/ other NSAIDs. Prolonged mean bleeding time w/ heparin. Reduced binding to plasma protein w/ salicylic acid. Reduced response to furosemide. Reduced clearance & increased plasma level w/ probenecid. Reduced renal clearance & elevated plasma level of lithium. Reduced clearance & elevated toxicity of methotrexate. Nondepolarizing muscle relaxants. Increased risk of renal impairment w/ ACE inhibitor. Seizure attack w/ antiepileptic drugs eg, phenytoin, carbamazepine. Hallucination w/ psychoactive drugs eg, fluoxetine, thiothixene, alprazolam. Not to be mixed w/ morphine.
ATC Classification
M01AB15 - ketorolac ; Belongs to the class of acetic acid derivatives and related substances of non-steroidal antiinflammatory and antirheumatic products.
Presentation/Packing
Form
Ketorolac Trometamol Darya-Varia inj 30 mg/mL
Packing/Price
1 mL x 5 × 1's
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