Lafutidine


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Gastric and duodenal ulcers; Stomal ulcers 10 mg twice daily. Gastric mucosal lesions 10 mg once daily. Pre-anesth medication 10 mg taken the night before surgery, followed by 10 mg 2 hr before anesth on the day of surgery.
Dosage Details
Oral
Gastric and duodenal ulcers, Stomal ulcers
Adult: 10 mg bid, once after breakfast, once after evening meal or before sleeping. Adjust dose according to patient's age and symptoms.
Elderly: Dose reduction or increase in dosing interval may be needed.

Oral
Gastric mucosal lesions
Adult: 10 mg once daily, after evening meal or before sleeping. Adjust dose according to patient's age and symptoms.
Elderly: Dose reduction or increase in dosing interval may be needed.

Oral
Pre-anaesthetic medication
Adult: 10 mg before sleeping on the day before operation, and 10 mg 2 hr before introduction of anaesthetic on the day of operation.
Elderly: Dose reduction or increase in dosing interval may be needed.
Renal Impairment
Dose reduction or increase in dosing interval may be needed.
Hepatic Impairment
Dose reduction or increase in dosing interval may be needed.
Contraindications
Lactation.
Special Precautions
Hepatic and renal impairment. Elderly.
Adverse Reactions
Constipation, hyperuricaemia, increase in LFT and total bilirubin, gynaecomastia, anorexia, hallucinations.
Potentially Fatal: Anaphylactic reactions, blood dyscrasias (e.g. agranulocytosis, thrombocytopenia).
Action
Description: Lafutidine is a histamine H2-antagonist with gastroprotective activity. It is used in the treatment of gastric ulcers and before general anaesthesia to reduce the incidence of aspiration pneumonia.
Pharmacokinetics:
Distribution: Protein binding: 88%.
Metabolism: Metabolised by CYP3A4 (mainly) and CYP2D6.
Excretion: Excreted in urine as unchanged drug and metabolites
Disclaimer: This information is independently developed by MIMS based on Lafutidine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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