Levocabastine


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : Ophth Allergic conjunctivitis As 0.05% susp: Instill 1 drop 2-4 times/day. Nasal Allergic rhinitis As 0.05% nasal spray: 1 spray into each nostril 2-4 times/day.
Dosage Details
Nasal
Allergic rhinitis
Adult: Spray 0.05% suspension in each nostril bid; increase to 3-4 times daily if necessary.
Child: ≥9 yr: Spray 0.05% suspension in each nostril bid; increase to 3-4 times daily if necessary.

Ophthalmic
Allergic conjunctivitis
Adult: Instil 1 drop of 0.05% suspension in the affected eye(s) bid; increase to 3-4 times daily if necessary. Discontinue if there is no improvement within 3 days.
Child: ≥9 yr: Instil 1 drop of 0.05% suspension in the affected eye(s) bid; increase to 3-4 times daily if necessary. Discontinue if there is no improvement within 3 days.
Special Precautions
Pregnancy. Severe renal impairment (nasal).
Adverse Reactions
Ophthalmic: Transient stinging and burning of the eyes, urticaria, dyspnoea, drowsiness and headache. Nasal: Headache, nasal irritation, somnolence and fatigue.
Action
Description: Levocabastine, a cyclohexylpiperidine derivative, is a long-acting, potent selective histamine H1-receptor antagonist.
Pharmacokinetics:
Absorption: Systemic availability: 60-80% (nasal); 30-60% (ocular).
Distribution: Protein-binding: 55%. Trace amounts detected in breast milk.
Excretion: Mainly via urine (70% as unchanged drug, 10% as metabolites); via faeces (20% as unchanged drug). 35-40 hr (elimination half-life).
Storage
Store at 15-30°C (59-86°F).
Disclaimer: This information is independently developed by MIMS based on Levocabastine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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