Usual dose: 250 or 500 mg once daily or bd continued for a min 48-72 hr after commencement of therapy.
Bacterial bronchitis exacerbations 500 mg once daily for 5-10 days.
Community acquired pneumonia 500 mg once daily, or bd for 10-14 days.
Sinusitis 500 mg once daily for 10-14 days.
Complicated UTI & acute pyelonephritis 250 mg once daily for 10 days.
Uncomplicated UTI in women 250 mg once daily for 3 days.
Uncomplicated skin & soft tissue infections 250-500 mg once daily for 7-10 days.
Complicated skin & soft tissue infections 500 mg once daily for 10-14 days.
Intra-abdominal infections 500 mg once daily in combination w/ an antibiotic w/ anaerobic coverage for 10-14 days.
Presence of bacteraemia or septicaemia in previously mentioned infections 500 mg bd for 10-14 days.
Renal impairment CrCl 20-50 mL/min 250 or 500 mg once-daily dose:
Initially, single normal dose, reduced to ½ the dose once daily. 500 mg bd dose: Initially 500 mg, then 250 mg 12 hrly.
10-19 mL/min 250 mg once-daily
dose:
Initially, single normal dose, reduced to 125 mg 48 hrly. 500 mg once-daily dose: Initially, a single normal dose, reduced to 125 mg 24 hrly. 500 mg bd dose: Initially, 500 mg, reduced to 125 mg 12 hrly.
<10 mL/min or patients on haemodialysis or continuous ambulatory peritoneal dialysis 250 mg once daily dose: Initially, a single normal dose, reduced to 125 mg 48 hrly. 500 mg once-daily dose:
Initially, a single normal dose, reduced to 125 mg 24 hrly. 500 mg bd dose: Initially 500 mg, reduced to 125 mg 24 hrly.
Sign Out
