Plasma concentrations are significantly decreased by the concomitant administration of therapeutic doses of aspirin.
When given together with preparations containing lithium or digoxin, diclofenac sodium may raise their plasma concentrations. Concomitant administration of glucocorticoids or other nonsteroidal anti-inflammatory agents may aggravate GI side effects.
Concurrent administration with two or more nonsteroidal anti-inflammatory agents may promote the occurrence of side effects.
Paracetamol should also be given with care to patients taking other drugs that affect the liver eg, the barbiturates.
The absorption of paracetamol may be accelerated by metoclopramide. Excretion may be affected and plasma concentrations altered when administered with probenecid.