Treatment of overdose should be symptomatic and supportive and may include the following: Induce vomiting or perform gastric lavage.
Administer activated charcoal.
Antacids may relieve adverse GI effects.
Nephritis or nephrotic syndrome, thrombocytopenia, hemolytic anaemia and severe cutaneous or other hypersensitivity reactions may respond to glucocorticoid administration.
Administer as required: Plasma volume expanders for severe hypotension; diazepam or other benzodiazepine for convulsions; vitamin K1 for hypoprothrombinemia; and/or dopamine plus dobutamine IV to prevent or reverse early indications of renal failure.
Hypotension may be counteracted by the use of dextran plasma, concentrated albumin or a vasopressor agent eg, noradrenaline.