Peripheral oedema may occasionally be severe but is fully reversible. As with other calcium antagonist drugs, peripheral oedema and skin erythema occur in a proportion of patients (5-10%) and facial flushing in 2.5% of patients. Complaints of fatigue was also reported more frequently than in placebo-treated patients.
There is evidence that these effects are more common in patients treated with doses greater than 10 mg daily. Clinical experience with amlodipine is still relatively limited and as this increases, a more reliable assessment of toxicity and side effects can be provided.