General: Since the vasodilation induced by Amlodipine is gradual in onset, acute hypertension has rarely been reported after oral administration of Amlodipine. Nonetheless, caution should be exercised when administering Amlodipine as with any other peripheral vasodilator particularly in patients with severe aortic stenosis.
Use in patients with Congestive heart failure: Although haemodynamic studies and a controlled trial in Class II-III heart failure patients have shown that Amlodipine did not lead to clinical deterioration as measured by exercise tolerance, left ventricular ejection fraction, and clinical symptomatology in general, all calcium channel blockers should be used with caution in patients with heart failure.
Beta-blocker Withdrawal: Amlodipine gives no protection against the danger of abrupt betablocker withdrawal, any such withdrawal should be gradual in reduction of the dose of betablocker.
Hepatic failure: Since Amlodipine is extensively metabolized by the liver, so caution should be exercised when administering Amlodipine to patients with hepatic impairment.