Loprazolam


Concise Prescribing Info
Indications/Uses
Short-term management of insomnia.
Dosage/Direction for Use
Adult : PO 1 mg at bedtime. May increase to 1.5 mg or 2 mg if necessary.
Dosage Details
Oral
Short-term management of insomnia
Adult: 1 mg at bedtime. May increase to 1.5 mg or 2 mg if necessary. Max duration: 4 wk.
Elderly: Initially, 0.5 mg at bedtime. Max: 1 mg.
Special Patient Group
Debilitated patients: Initially, 0.5 mg at bedtime. Max: 1 mg.
Contraindications
Acute pulmonary insufficiency, severe resp insufficiency, myasthenia gravis, phobic or obsessional states and sleep apnoea syndrome. Monotherapy in depression or anxiety associated w/ depression and chronic psychosis and alcohol intake.
Special Precautions
Patient w/ personality disorders, history of alcoholism or drug abuse, chronic pulmonary insufficiency, cerebrovascular disease. Avoid abrupt withdrawal. Chronic renal or hepatic impairment. Elderly and debilitated patients. Pregnancy and lactation.
Adverse Reactions
Headache, nausea, drowsiness, hypotonia, blurred vision, dizziness, ataxia. Rarely, paradoxical aggressive outbursts, excitement, confusion and uncovering of depression w/ suicidal tendencies; hypotension, GI and visual disturbances, skin rashes, urinary retention, changes in libido, blood dyscrasias, jaundice.
Patient Counseling Information
This drug may cause drowsiness, sedation, amnesia, impaired concentration and muscular weakness, if affected, do not drive or operate machinery.
Overdosage
Symptoms: Drowsiness, ataxia, dysarthria, nystagmus, and occasionally, resp depression and coma. Management: Symptomatic treatment. May perform gastric lavage shortly after ingestion. Consider flumazenil as antidote.
Drug Interactions
Potentiation by other drugs acting in the CNS or w/ cisapride. Additive synergy w/ neuromuscular depressants (e.g. curare-like drugs and muscle relaxants). Enhanced central depressive effects w/ CNS depressants (e.g. antipsychotics, narcotic analgesics, anaesth).
Food Interaction
Enhanced sedative effects w/ alcohol.
Action
Description: Loprazolam is an intermediate-acting benzodiazepine which potentiates central inhibitory GABA-mediated transmission.
Storage
Store below 25°C. Protect from light.
ATC Classification
N05CD11 - loprazolam ; Belongs to the class of benzodiazepine derivatives. Used as hypnotics and sedatives.
References
Buckingham R (ed). Loprazolam Mesilate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 30/03/2016.

Joint Formulary Committee. Loprazolam. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 30/03/2016.

Disclaimer: This information is independently developed by MIMS based on Loprazolam from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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