Loracarbef


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Uncomplicated UTI; Skin and soft tissue infections; Pharyngitis; Tonsillitis 200 mg/day. Treatment duration: Uncomplicated UTI and skin and soft tissue infections: 7 days; Pharyngitis and tonsillitis: 10 days. Secondary bacterial infection of acute bronchitis; Sinusitis; Pneumonia; Pyelonephritis 400 mg 12 hrly.Treatment duration: Acute bacterial exacerbation of chronic bronchitis: 7 days; Sinusitis: 10 days; Pneumonia and pyelonephritis: 14 days. Secondary bacterial infection of acute bronchitis 200-400 mg 12 hrly for 7 days.
Dosage Details
Oral
Secondary bacterial infection of acute bronchitis
Adult: 200-400 mg 12 hrly for 7 days.

Oral
Skin and soft tissue infections
Adult: 200 mg 12 hrly for 7 days.
Child: 6 mth-12 yr: 7.5 mg/kg 12 hrly for 7 days.

Oral
Uncomplicated urinary tract infections
Adult: 200 mg daily for 7 days.

Oral
Acute bacterial exacerbation of chronic bronchitis
Adult: 400 mg 12 hrly for 7 days.

Oral
Acute otitis media
Child: 6 mth-12 yr as oral suspension: 15 mg/kg 12 hrly for 10 days.

Oral
Sinusitis
Adult: 400 mg 12 hrly for 10 days.
Child: 6 mth-12 yr: 15 mg/kg 12 hrly for 10 days.

Oral
Pneumonia, Pyelonephritis
Adult: 400 mg 12 hrly for 14 days.

Oral
Pharyngitis, Tonsillitis
Adult: 200 mg 12 hrly for 10 days.
Child: 6 mth-12 yr: 7.5 mg/kg 12 hrly for 10 days.
Renal Impairment
Patients with CrCl of 10-49 mL/min: Half the usual dose at the usual dosage interval or full dose at twice the usual interval; <10 mL/min: Usual dose every 3-5 days. Patients on haemodialysis should receive another dose following dialysis.
Administration
Should be taken on an empty stomach. Take 1 hr before or at least 2 hr after meals.
Contraindications
Hypersensitivity to β-lactams.
Special Precautions
Impaired renal function, history of colitis.
Adverse Reactions
Diarrhoea, nausea, vomiting, abdominal pain; headache; skin rashes; abnormalities in haematological parameters; elevations in hepatic enzymes, hepatic dysfunction.
Drug Interactions
Plasma concentration is increased by probenecid.
Action
Description: Loracarbef is a carbacephem antibiotic. It is bactericidal through binding to essential target proteins of the bacterial cell wall, leading to inhibition of cell-wall synthesis, thus preventing cell division.
Pharmacokinetics:
Absorption: Well absorbed from GI tract. Peak plasma levels after 1.2 hr (capsule) or 40-60 min (liquid). Absorption delayed significantly by food.
Distribution: 25% bound to plasma proteins.
Excretion: Excreted in the urine as unchanged drug.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Loracarbef from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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