Acute or chronic hepatitis, nephritis, history of breast cancer, diabetes, hyperthyroidism, high BP, thrombus, sickle cell anemia, unexplained vag bleeding, serious liver disease or jaundice, rheumatic disease or epilepsy. Women w/ childbearing potential & those who take anticoagulants. Pregnancy & lactation (during 1st 6 wk postpartum).
Do not use in women w/ a history of irregular periods or those >45 yr. Implant may be removed if necessary in case patient experiences intolerable effects. Expect fertility to return promptly in women w/ removed implants & who use no other form of contraception. Remove implant at the end of 4 yr. Avoid damaging the implant during removal.
Irregular menstrual bleeding. Nausea; fatigue, back or generalized pain; wt loss or gain; abdominal discomfort; mood swings, decreased libido, depression; pain or itching at insertion site; cervical inflammation, ovarian cysts; UTI; benign breast lumps, breast discharge; worsening of existing acne or excess face or body hair, hair loss, rash, itching or mild skin discoloration.
Drug Interactions
Interfered efficacy w/ barbiturates, phenytoin, carbamazepine, oxcarbazepine, primidone, topiramate & rifampicin. Effectiveness may be diminished w/ herbal products containing St. John's wort (Hypericum perforatum).
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