Magnesium gluconate


Concise Prescribing Info
Indications/Uses
Dietary supplementation.
Dosage/Direction for Use
Adult : PO Adjust according to individual requirement. RDA (elemental magnesium) 19-30 yr: female: 310 mg/day, pregnant female: 350 mg/day, male: 400 mg/day. ≥31 yr: female: 320 mg/day, pregnant female: 360 mg/day, male: 420 mg/day.
Dosage Details
Oral
Dietary supplement
Adult: Adjust according to individual requirement. RDA (elemental magnesium): 19-30 yr: Female: 310 mg/day, pregnant female: 350 mg/day, male: 400 mg/day. ≥31 yr: Female: 320 mg/day, pregnant female: 360 mg/day, male: 420 mg/day.
Special Precautions
Risk of hypermagnesaemia in patients with renal impairment. Caution in myasthenia gravis. Take with food to reduce incidence of diarrhoea.
Adverse Reactions
Gastrointestinal irritation, diarrhoea.
Overdosage
Hypermagnesaemia following oral admin is uncommon except in patients with renal impairment. Symptoms of hypermagnesaemia: Respiratory depression and loss of deep tendon reflexes due to neuromuscular blockade; nausea, vomiting, flushing, hypotension, drowsiness, bradycardia and muscle weakness. Treatment: In patients with normal renal function, IV fluids or furosemide may be given to promote Magnesium excretion. In patients with symptomatic hypermagnesaemia, slow IV inj of calcium gluconate can be used to antagonise the cardiac and neuromuscular effects of Magnesium.
Drug Interactions
Oral magnesium salts may decrease absorption of bisphosphonates, quinolone antibiotics and tetracycline derivatives; admin should be separated apart if concomitant use is required. Magnesium-containing products may reduce absorption of eltrombopag by 70%; separate admin by at least 4 hr. Calcitriol may increase serum concentrations of Magnesium salts. Magnesium salts may decrease serum concentrations of mycophenolate if used concurrently; monitor for reduced effects of mycophenolate. Concomitant use of trientine and magnesium salt may reduce serum concentrations of both agents.
Action
Description: Magnesium is essential to many enzymatic reactions in the body, acting as a cofactor in protein synthesis and carbohydrate metabolism. 17.1 g of Magnesium Gluconate (anhydrous) is equivalent to about 1 g of magnesium. Each g of Magnesium Gluconate (anhydrous) represents about 2.4 mmol of magnesium.
Pharmacokinetics:
Absorption: Oral: About one-third is absorbed from the small intestine. The fraction of magnesium absorbed is inversely proportional to amount ingested.
Distribution: Plasma protein binding: About 25-30%. Magnesium crosses the placenta.
Excretion: Oral: Via urine (absorbed fraction); faeces (unabsorbed fraction).
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Magnesium gluconate from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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