The following adverse experiences have also been reported.
[Common (approximately 1/100, <1/10), uncommon (approximately 1/1000, <1/100), rare (approximately 1/10,000, <1/1000), very rare (<1/10,000) including isolated cases.]
Immune System Disorders: Rare: Hypersensitivity reactions including urticaria and angioedema.
Metabolism and Nutrition Disorders: Rare: Symptomatic hypocalcaemia, often in association with predisposing conditions.
Nervous System Disorders: Common: Headache.
Eye Disorders: Rare: Uveitis, scleritis, episcleritis.
Gastrointestinal Disorders: Common: Abdominal pain, dyspepsia, constipation, diarrhea, flatulence, oesophageal ulcer, dysphagia, abdominal distention, acid regurgitation. Uncommon: Nausea, vomiting, gastritis, oesophagitis, oropharyngeal ulceration, upper gastrointestinal perforation, ulcers, bleeding (PUBs).
Skin and Subcutaneous Tissue Disorders: Uncommon: Rash, pruritus, erythema. Rare: Rash with photosensitivity. Very Rare: Isolated cases of severe skin reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis.
Musculoskeletal, Connective Tissue and Bone Disorders: Common: Musculoskeletal (bone, muscle or joint) pain. Rare: Osteonecrosis of the jaw has been reported in patients treated by bisphosphonates.