Maxx Omega 3

Maxx Omega 3

Manufacturer:

Mega Lifesciences

Distributor:

Maxxcare
Full Prescribing Info
Contents
Fish oil [omega-3 fatty acids (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)].
Description
Each softgel capsule contains: Fish oil concentrated (as Triglyceride form) 1000 mg, providing Omega-3 Fatty acids 600 mg (as Eicosapentaenoic acid (EPA) 300 mg and Docosahexaenoic acid (DHA) 200 mg).
Excipients/Inactive Ingredients: Gelatin, glycerin.
Action
Pharmacology: Pharmacodynamics: Omega-3 fatty acids (predominantly EPA and DHA) can reduce hepatic very-low density lipoprotein triglyceride (VLDL-TG) synthesis/secretion and enhances triglyceride clearance from circulating VLDL particles. They may equally accelerate chylomicron triglyceride clearance by promoting increased lipoprotein lipase activity. They also have anti-inflammatory, anti-thrombotic and immunomodulatory actions.
Pharmacokinetics: Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA)-laden triacylglycerols, following ingestion, undergo hydrolysis via lipases to form monoglycerides and free fatty acids. In the enterocytes, reacylation takes place reforming triacylglycerols, which are then assembled with phospholipids, cholesterol and apoproteins into chylomicrons. The chylomicrons are released into the lymphatics from whence they are transported to the systemic circulation. In the circulation, the chylomicrons are degraded by lipoprotein lipase, and EPA and DHA are transported by the circulation to various tissues of the body where they are used mainly for the synthesis of phospholipids. These phospholipids are incorporated into the cell membranes of the red blood cell, platelets and CNS cells among others. EPA and DHA are mainly found in the phospholipid components of the cell membranes. DHA is taken up by the brain in preference to other fatty acids. DHA can partially reconvert to DHA, which can partially retroconvert to EPA, and EPA may partially convert to DHA. Enteral absorption of EPA and DHA is at least as good from semi-synthetic ethyl esters as it is from the natural forms.
Indications/Uses
As an adjunct to therapy to reduce triglyceride levels in adult patients with severe (≥500 mg/dL) hypertriglyceridemia.
Dosage/Direction for Use
Take 3 capsules twice daily with meals.
Do not break, open, crush, dissolve or chew Maxx Omega 3.
Administration: Oral administration.
Overdosage
In the event of an overdose, the patient should be treated symptomatically, and general supportive care measures instituted, as required.
Contraindications
Hypersensitivity or intolerance to any component of the product.
Special Precautions
Omega-3 fatty acids have antithrombotic activity and should be given with caution to patients with hemorrhagic disorders or to those receiving anticoagulants or other drugs affecting coagulation. Hepatic function should be monitored in patients with hepatic impairment, particularly if receiving high doses. Caution may also be required in asthmatic patients sensitive to aspirin since omega-3 fatty acids may affect prostaglandin synthesis.
Use In Pregnancy & Lactation
No data available. In accordance with general medical practice, the product should not be used during pregnancy and lactation without medical advice.
Side Effects
The most common adverse effects of omega-3 fatty acid preparations are gastrointestinal disturbances, particularly at high doses, including nausea, eructation, vomiting, abdominal distension, diarrhea, and constipation.
Drug Interactions
Interactions may occur between fish oil and aspirin and other non-steroidal anti-inflammatory drugs and herbs such as garlic and ginkgo. Such interactions might be manifested by increased susceptibility to bruising, nosebleeds, hemoptysis, hematemesis, hematuria and blood in the stool.
Storage
Store below 25°C in a dry place, away from direct sunlight.
ATC Classification
C10AX06 - omega-3-triglycerides incl. other esters and acids ; Belongs to the class of other lipid modifying agents.
Presentation/Packing
Softgel cap (oblong shaped, natural colored) 3 x 10's.
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