Methylcobalamin is relatively safe and devoid of side effects. However, it could infrequently cause the following reactions.
pulmonary edema and congestive heart failure early in treatment; peripheral vascular thrombosis.
mild transient diarrhea.
itching; transitory exanthema.
feeling of swelling of entire body.
The common adverse effects of pregabalin given alone, or in combination with other anti-epileptic agents are dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, and "thinking abnormal" (primarily difficulty with concentration/attention). Asthenia, ataxia, abnormal gait, paresthesias, diplopia, blurred vision, visual field defect, nystagmus, nausea, tremor, vertigo, headache, nervousness, confusion and edema are other significant side effects of pregabalin.
Effects are further classified within body system categories and enumerated in order of decreasing frequency using the following definitions: frequent adverse events are defined as those occurring in at least 1/100 patients; Infrequent adverse events are those occurring in 1/100 to 1/1000 patients; rare events are those occurring in fewer than 1/1000 patients.
Body as a whole:
Frequent: Abdominal pain, Allergic reaction, Fever, Flu syndrome, accidental injury; Infrequent: Abscess, Cellulitis, Chills, Malaise, Neck rigidity, Overdose, Pelvic pain, Chest pain, Photosensitivity reaction, Suicide attempt; Rare: Anaphylactoid reaction, Ascites, Granuloma, Hangover effect, Intentional injury, Retroperitoneal Fibrosis, Shock, Suicide.
Infrequent: Deep thrombophlebitis, Heart failure, Hypotension, Postural hypotension, Retinal vascular disorder, Syncope; Rare: ST depressed, Ventricular Fibrillation.
Frequent: Gastroenteritis, Nausea, Diarrhea, Flatulence, Dry mouth, Increased appetite, Constipation; Infrequent: Cholecystitis, Cholelithiasis, Colitis, Dysphagia, Esophagitis, Gastritis, Gastrointestinal hemorrhage, Melena, Mouth ulceration, Pancreatitis, Rectal hemorrhage, Tongue edema; Rare: Aphthous stomatitis, Esophageal ulcer.
Hemic and Lymphatic System:
Frequent: Ecchymosis; Infrequent: Anemia, Eosinophilia, Hypochromic anemia, Leukocytosis, Leukopenia, Lymphadenopathy, Thrombocytopenia; Rare: Myelofibrosis, Polycythemia, Prothrombin decreased, Purpura, Thrombocytopenia.
Metabolic and Nutritional Disorders:
Frequent: Weight gain, Peripheral edema; Rare: Glucose Tolerance Decreased, Hypoglycemia, Urate crystalluria.
Frequent: Arthralgia, Leg cramps, Myalgia, Myasthenia; Infrequent: Arthrosis; Rare: Generalised Spasm.
Frequent: Headache, Nervousness, Dizziness, Vertigo, Somnolence, Ataxia, Tremor, Thinking abnormal, Amnesia, Speech disorder, Incoordination, Abnormal gait, Twitching, Confusion, Anxiety, Depersonalization, Hypertonia, Hypesthesia, Libido decreased, Nystagmus, Paresthesia, Stupor, Twitching, Euphoria; Infrequent: Abnormal dreams, Agitation, Apathy, Aphasia, Circumoral paresthesia, Dysarthria, Hallucinations, Hostility, Hyperalgesia, Hyperesthesia, Hyperkinesia, Hypokinesia, Hypotonia, Libido increased, Myoclonus, Neuralgia; Rare: Addiction, Cerebellar syndrome, Cogwheel rigidity, Coma, Delirium, Delusions, Dysautonomia, Dyskinesia, Dystonia, Encephalopathy, Extrapyramidal syndrome, Guillain Barre syndrome, Hypoalgesia, Intracranial hypertension, Manic reaction, Paranoid reaction, Peripheral neuritis, Psychotic depression, Schizophrenic reaction, Torticollis, Trismus.
Frequent: Bronchitis, Dyspnea; Rare: Apnea, Atelectasis, Bronchiolitis, Hiccup, Laryngismus, Lung edema, Lung fibrosis, Yawn.
Skin and Appendages:
Frequent: Pruritus, Face swelling; Infrequent: Alopecia, Dry skin, Eczema, Hirsutism, Skin ulcer, Urticaria, Vesiculobullous rash; Rare: Angioedema, Exfoliative dermatitis, Lichenoid dermatitis, Melanosis, Petechial rash, Purpuric rash, Pustular rash, Skin atrophy, Skin necrosis, Skin nodule, Stevens Johnson syndrome, Subcutaneous nodule.
Frequent: Conjunctivitis, Diplopia, Blurred vision, Abnormal vision, Otitis media, Tinnitus; Infrequent: Abnormality of accommodation, Blepharitis, Dry eyes, Eye hemorrhage, Hyperacusis, Photophobia, Retinal edema, Taste loss, Taste perversion; Rare: Anisocoria, Blindness, Corneal ulcer, Exophthalmos, Extraocular, Palsy, Iritis, Keratitis, Keratoconjunctivitis, Miosis, Mydriasis, Night blindness, Ophthalmoplegia, Optic atrophy, Papilledema, Parosmia, Ptosis, Uveitis.
Frequent: Anorgasmia, Impotence, Urinary frequency, Urinary incontinence; Infrequent: Abnormal ejaculation, Albuminuria, Amenorrhea, Dysmenorrhea, Dysuria, Hematuria, Kidney calculus, Leukorrhea, Metrorrhagia, Nephritis, Oliguria, Urinary retention; Rare: Acute kidney failure, Balanitis, Bladder Neoplasm, Cervicitis, Dyspareunia, Epididymitis, Female lactation, Glomerulitis.