Menotrophin is used to treat infertility in men and women.
It is composed of a highly purified mixture of two hormones, follicle stimulating hormone and luteinising hormone, which are natural hormones produced in both men and women. These hormones help the reproductive organs to work normally.
This medicine helps induce ovulation in women who are unable to become pregnant because their ovaries cannot produce eggs and in those who are unresponsive to other treatments. It may also stimulate the development of follicles in the ovaries for assisted reproduction programmes.
Menotrophin may also be used with another medicine called human chorionic gonadotrophin (hCG) to help produce sperm in men who are infertile due to low levels of certain hormones.
Menotrophin is to be injected subcutaneously (into the fatty layer under the skin, usually in the abdomen area) or intramuscularly (into the muscles).
Your doctor or nurse will administer the injection for you. If you or your caregiver had been given the proper training on the preparation and injection techniques of this medicine, you or your caregiver may do the administration.
Use Menotrophin exactly as directed by your doctor or according to the instructions on the label. Do not administer more or less than instructed by your doctor.
Remember to rotate the injection sites. Do not inject into the same area all the time. New injection sites should be at least 1.5 inches away from the previous injection site. Do not inject near the navel (belly button).
The dose of this medicine will be decided by your doctor. Your doctor will advise you on the course of the treatment depending on your response to the medication.
Ensure that you keep all appointments with your doctor so that you do not miss any doses. Your doctor also needs to regularly monitor your response to Menotrophin.
If you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.
If you or a caregiver had been trained to administer this medicine and missed a dose, DO NOT double a dose under any circumstances.
Inform your doctor or pharmacist immediately if you forgot to administer your dose.
Alert your doctor if you have the following conditions:
- tumour of the pituitary gland (a pea-sized gland at the base of the brain) or hypothalamus (a small region of the brain)
- uncontrolled problems with your thyroid, adrenal or pituitary glands
- cancer of the womb, ovaries, or breasts
- abnormal vaginal bleeding with an unknown cause
- cysts on the ovaries or enlarged ovaries that are not due to polycystic ovarian disease (a hormonal disorder characterised by irregular menstruation, acne or unwanted hair growth)
- primary ovarian failure (a condition when the ovaries stop working normally before the age of 40)
- structural problems in the reproductive organs e.g. womb, fallopian tubes, ovaries, cervix
- early menopause
- cancer of the testicles
- prostate cancer
as Menotrophin may not be suitable for you.
Do not use this medicine if you are pregnant or breastfeeding.
Inform your doctor if you have the following conditions:
Why is it important to keep my appointments with the doctor?
- personal or family history of blood clot disorder
- thrombophilia (a condition that increases your tendency to form blood clots)
- history of fallopian tube disease
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
- To check the appropriateness of Menotrophin medication, a thorough evaluation and assessment (e.g. pregnancy or fertility tests) may be needed before treatment initiation.
- Routine tests (e.g. ultrasound, estradiol levels) may be done while you are being treated with this medicine. Your doctor will advise you about how often you need to have these tests.
- Regular monitoring for signs of ovarian hyperstimulation syndrome (a serious medical problem that can happen when the ovaries are over-stimulated) may also be needed.
Menotrophin may cause any of the following side effects: headache, dizziness, stomach pain or discomfort, nausea, vomiting, diarrhoea, hot flush, tiredness, pain or swelling at the injection site, and breast pain, tenderness, or discomfort.
Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
- signs of allergic reactions e.g. rashes, breathlessness, swelling of the face, eyes or mouth
- pain, swelling and tenderness in the leg accompanied by redness or warmth
- fast breathing, rapid heart rate, chest pain
- signs of ovarian hyperstimulation syndrome e.g. shortness of breath, decreased urination, severe stomach or pelvic pain, bloating, sudden weight gain
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Inform your doctor and pharmacist if you are taking other medicines to treat infertility such as clomifene citrate.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
Store in the refrigerator between 2-8°C, or at room temperature below 25°C. Protect from light.
Do not freeze this medicine otherwise, it will no longer be effective and should not be used.
If you notice that the injection has changed colour or has become cloudy, do not use it. Throw it away and use a new injection.
Available products of Menotrophin may vary with their storage requirements. Ask your doctor or pharmacist how to properly store this medicine.
Medicines must not be used past the expiry date.