Pneumonia & nosocomial pneumonia; UTI & intra-abdominal infections; gynaecological infections eg, endometritis & pelvic inflammatory disease; bacterial meningitis; septicaemia. Empiric treatment for presumed infections in patients w/ febrile neutropenia used as monotherapy or in combination w/ antiviral or antifungal agents.
IV As an IV bolus inj over approx 5 min or IV infusion over approx 15-30 min. AdultPneumonia, UTI, gynaecological infections eg, endometritis 500 mg 8 hrly. Hospital-acquired pneumonia, peritonitis, presumed infections in febrile neutropenic patients, septicaemia 1 g 8 hrly. Meningitis 2 g 8 hrly. Childn >3 mth & up to 12 yr 10-20 mg/kg 8 hrly depending on type & severity of infection, susceptibility of pathogen & condition of the patient; weighing >50 kg Adult dose. Meningitis 40 mg/kg 8 hrly. Febrile episodes in neutropenic patients 20 mg/kg 8 hrly. Renal impairment: CrCl 26-50 mL/min 1 u dose 12 hrly; 10-25 mL/min ½u dose 12 hrly; <10mL/min ½ u dose 24 hrly.
Hypersensitivity, partial cross-allergenicity between other carbapenems & β-lactams, penicillins & cephalosporins; discontinue use & take appropriate measures if allergic reactions occur. Continuously monitor for possible overgrowth of non susceptible organisms. Not recommended in infections caused by methicillin resistant staphylococci. Pseudomembranous colitis may occur; consider in patients who develop diarrhea. History of GI complaints, particularly colitis. Concurrent use w/ potentially nephrotoxic drugs. Carefully monitor transaminase & bilirubin levels in patient w/ hepatic disease. Pregnancy & lactation. Not recommended in infant <3 mth.
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