Micro Labs


Zizawa Healthcare
Concise Prescribing Info
Acute alcohol intoxication. Supportive treatment of acute & chronic liver diseases, alcoholic fatty liver.
Dosage/Direction for Use
Adult Acute ethanol intoxication 500-1,000 mg daily. Alcoholic fatty liver, supportive treatment of acute & chronic liver diseases 1,000 mg daily.
Special Precautions
CHF w/ unstable or acute heart failure. Risk of lactic acid accumulation increases w/ the degree of renal impairment. Discontinue treatment in patients w/ stress-related states eg, fever, trauma, infection or surgery. Temporarily discontinue metformin for 48 hr in patients undergoing radiologic studies involving intravascular administration of iodinated contrast materials. Monitor renal function regularly. May impair ability to drive or operate machinery. Pregnancy & lactation. Elderly.
Adverse Reactions
Anorexia, nausea, vomiting, diarrhoea, wt loss, flatulence, occasional metallic taste; weakness; hypoglycaemia; rash, malabsorption of vit B12; chest discomfort, flushing, palpitation, chills, Potentially Fatal: Lactic acidosis in presence of renal failure & alcoholism.
Drug Interactions
Additive effect w/ sulphonylurea. May affect glycaemic control w/ diuretics, corticosteroids, phenothiazines, thyroid products, oestrogens, OCs, phenytoin, nicotinic acid, sympathomimetics, Ca channel blockers, chlorpromazine & INH. Increased metformin effects by ACE inhibitors, disopyramide, MAOIs. Cimetidine may increase serum levels of metformin. Increased risk of metformin-induced lactic acidosis w/ concurrent use w/ contrast agents. May decrease anticoagulant effect of phenprocoumon; routine anticoagulant monitoring is recommended. Potentially fatal: Lactic acidosis w/ alcohol. Thrombocytopenia w/ ketotifen.
MIMS Class
Cholagogues, Cholelitholytics & Hepatic Protectors
ATC Classification
A05BA09 - metadoxine ; Belongs to the class of drugs used in liver therapy.
Metadoxil FC tab 500 mg
5 × 6's
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