Metadoxil Mechanism of Action



Micro Labs


Zizawa Healthcare
Full Prescribing Info
Pharmacotherapeutic Group: Hepato protective.
Pharmacology: Mechanism of Action: Metadoxine antagonizes the lipid peroxidation in liver cells, restoring liver damage resulting from prolonged alcohol intake and reduces fatty liver in chronic hepatitis.
Furthermore, metadoxine acts specifically on the neurotransmitter systems involved in alcoholic Intoxication, increasing the release of γ-aminobutyric acid (GABA) and acetylcholine.
Metadoxine improves ethanol metabolism, reducing plasma ethanol levels during alcohol intake and improves the cognitive impairment, as well as the main psychological symptoms (aggressiveness, agitation, mood and behavioral disturbances) due to occasional or prolonged alcohol abuse.
Therapeutic Efficacy: Metadoxil reduces the stay-time of ethanol in the organism; thus, minimizing its toxic effects on cells. Metadoxil also protects cell structure and function, acting on those biochemical processes which defend them.
Due to these peculiar pharmacological properties, Metadoxil reduces detoxification time in acute ethanol intoxication, and prevents or reduces the hepatic and neuropsychic consequences of habitual intake of alcohol.
Metadoxine is Pyridoxine pidolate. Metadoxine has a direct effect on alcohol metabolism. It accelerates the transformation of alcohol into acetaldehyde and is excreted in urine. It aids in preventing liver damage resulting from prolonged alcohol intake and helps in reversing fatty liver. It improves Alcohol metabolism and accelerates the elimination of alcohol from the blood. Metadoxine reduces the toxic effects of alcohol.
Antifibrotic agent: In hepatic stellate cells, Metadoxine prevents the collagen synthesis & reduces fibrosis. Metadoxine acts as Antifibrotic agent. Metadoxine is a synthetic antioxidant, provides stronger antioxidant protection. Metadoxine, prevents the redox imbalance and tumor necrosis factor (TNF-α) one of the earliest event in hepatic damage. Metadoxine increases the cerebral release of GABA and acetylcholine and the cerebral levels of ATP. Metadoxine is therefore an antagonist of alcohol-metabolic effects and helps to restore normal neuropsychological behavior.
Pharmacokinetics: Absorption: It is readily absorbed after oral administration.
Distribution: It is mainly distributed in the body in protein bound form. It is stored primarily in the liver and to a lesser extent muscle and brain.
Metabolism: It is metabolised in the liver.
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