Metadoxine


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Acute alcohol intoxication 0.5-1 g/day. Alcoholic fatty liver; Adjunct in acute and chronic liver diseases 1 g/day. IV/IM Acute alcohol intoxication 300-600 mg/day. Alcoholic fatty liver; Adjunct in acute and chronic liver diseases 300 mg/day.
Dosage Details
Oral
Acute alcohol intoxication
Adult: 500-1000 mg daily.

Oral
Alcoholic fatty liver, Supportive treatment of acute and chronic liver diseases
Adult: 1000 mg daily.

Parenteral
Acute alcohol intoxication
Adult: 300-600 mg daily IM/IV.

Parenteral
Alcoholic fatty liver, Supportive treatment of acute and chronic liver diseases
Adult: 300 mg daily IM/IV.
Contraindications
Pregnancy and lactation.
Drug Interactions
May reduce effects of levodopa; administer levodopa with a dopa-decarboxylase inhibitor to minimise interaction.
Action
Description: Metadoxine enhances the elimination of alcohol from blood and tissues, which leads to faster recovery from alcohol intoxication. In the early stages of alcoholic liver disease, metadoxine has been suggested to prevent the redox imbalance of the hepatocytes and to prevent TNF-α induction.
Disclaimer: This information is independently developed by MIMS based on Metadoxine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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