Metergoline


Generic Medicine Info
Indications and Dosage
Oral
Hyperprolactinaemia
Adult: 12 mg daily in divided doses, up to 24 mg daily in hyperprolactinaemic men.
Contraindications
Lactation (discontinue from the 1st day of treatment).
Special Precautions
Pregnancy may occur during treatment for amenorrhoea-galactorrhoea, even without resumption of menstruation. Perform pregnancy test every 20 days and discontinue treatment. Nonhormonal contraceptives may be used.
Adverse Reactions
Nausea, vomiting, insomnia, drowsiness, anxiety, dizziness, weakness.
Action
Description: Metergoline, an ergot derivative, is a dopamine agonist with actions similar to bromocriptine. It is also a serotonin antagonist. It appears to take part in hypothalamic-pituitary neuroendocrine control, stimulating adrenocorticotropic hormone and prolactin release.
Pharmacokinetics:
Absorption: Well-absorbed (oral).
Metabolism: Extensively hepatic.
Excretion: Via faeces (70-80%).
MIMS Class
Antimigraine Preparations / Other Drugs Affecting Hormonal Regulation
Disclaimer: This information is independently developed by MIMS based on Metergoline from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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