Methoxamine


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : IV Hypotensive states Emergency: 3-5 mg via slow inj. May supplement w/ IM inj for more prolonged effect. Repeat a dose 15 mins later if needed. Paroxysmal supraventricular tachycardia 10 mg via slow inj. IM Hypotensive states Moderate hypotension: 5-10 mg. Prevention of hypotension during anesth 10-15 mg shortly before or w/ spinal anesth. Up to 20 mg may be needed. Repeat a dose 15 mins later if needed.
Dosage Details
Intramuscular
Prophylaxis of hypotension during anaesthesia
Adult: 10-15 mg shortly before or with spinal anaesthesia. Up to 20 mg may be required at high levels of anaesthesia. About 15 min should elapse before repeating a dose.

Intramuscular
Hypotensive states
Adult: As hydrochloride: Moderate hypotension: 5-10 mg.

Intravenous
Hypotensive states
Adult: As hydrochloride: Emergency: 3-5 mg by slow inj. May be supplemented by IM inj for a more prolonged effect. About 15 min should elapse before repeating a dose.

Intravenous
Paroxysmal supraventricular tachycardia
Adult: As hydrochloride: 10 mg by slow inj over 3-5 min.
Contraindications
Severe hypertension.
Special Precautions
Hyperthyroidism, bradycardia, partial heart block, myocardial disease, poor left ventricular function, severe arteriosclerosis, pre-existing vascular disease. Pregnancy and lactation.
Adverse Reactions
Excessive BP elevations particularly with high dosage, ventricular ectopic beats, reflex bradycardia; nausea, vomiting; headache (often severe), anxiety; sweating, pilomotor response; feeling of cold and other skin sensations resulting from piloerection; uterine hypertonus, fetal bradycardia, urinary urgency.
Overdosage
Symptoms: Undesirable elevations in BP and/or bradycardia. Management: α-adrenergic blocking agent (e.g. phentolamine) may be used for severe hypertension. Bradycardia may be abolished by atropine.
Drug Interactions
Potentiation of pressor effects with MAOIs, TCAs, vasopressin, ergotamine, ergonovine or methylergonovine, sympathomimetic decongestants, certain appetite suppressants and amphetamine-like psychostimulants.
Lab Interference
May increase plasma cortisol and adrenocorticotropic hormone (ACTH) levels; use caution when interpreting plasma cortisol and ACTH levels.
Action
Description: Methoxamine has mainly direct effects on α-adrenergic receptors. It causes prolonged peripheral vasoconstriction and consequently a rise in arterial BP.
Onset: IV: Within 0.5-2 min. IM: Within 15-20 min.
Duration: IV: 10-15 min. IM: 1.5 hr.
Storage
Store at controlled room temperature (15-30°C). Protect from light.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Methoxamine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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