Mexib

Mexib

etoricoxib

Manufacturer:

Mepro Pharma

Distributor:

Royal Distribution

Marketer:

ESTI Pharma
Concise Prescribing Info
Contents
Etoricoxib
Indications/Uses
Acute & chronic symptomatic treatment of OA & RA. Acute gouty arthritis. Relief of acute & chronic musculoskeletal pain.
Dosage/Direction for Use
OA 60 mg once daily. RA 90 mg once daily. Acute gouty arthritis 120 mg once daily. Acute pain 120 mg once daily. Chronic musculoskeletal pain 60 mg once daily. Mild hepatic insufficiency Max: 60 mg once daily. Moderate hepatic insufficiency (Child-Pugh score 7-9) Max: 60 mg every alternate day.
Administration
May be taken with or without food.
Contraindications
Special Precautions
Patients suffering from CHD or CV disorder. Rehydrate patients w/ considerable dehydration prior to starting therapy. Consider possibility of fluid retention, oedema or HTN in patients w/ preexisting oedema, HTN or heart failure. Do not discontinue antiplatelet therapy if etoricoxib treatment is ongoing; if indicated, consider in patients at risk for or w/ a history of CV or other thrombotic effects. Patients w/ history of ischemic heart disease. GI ulcers/ulcer complications may occur; who are at higher risk for perforation, ulcers & bleeding eg, w/ prior history of GI perforation, ulcers & bleeding, & patients >65 yr. Previous acute asthmatic attacks, urticaria, or rhinitis precipitated by salicylates or non-selective COX inhibitors. May mask fever, which is a sign of infection. Not recommended in patients w/ advanced renal disease; closely monitor renal function if therapy must be initiated. Patients w/ pre-existing severe renal function impairment, uncompensated heart failure or cirrhosis; consider monitoring of renal function or discontinue if needed. Elevations of alanine &/or aspartate aminotransferase (approx 3 times the upper limit of normal). Signs & symptoms of liver dysfunction, abnormal liver function tests. Avoid use during late pregnancy. Lactation. Childn.
Adverse Reactions
Asthenia, fatigue, dizziness, lower extremity oedema, HTN, dyspepsia, heartburn, nausea, & headache. Hypersensitivity reactions, including anaphylactic/anaphylactoid reaction, insomnia, dysgeusia, somnolence, CHF, bronchospasm, abdominal pain, oral ulcers, peptic ulcer including perforation & bleeding (mainly in elderly patients), vomiting, angioedema, rash, pruritus, urticaria, renal insufficiency & renal failure.
Drug Interactions
Monitor INR values in patients receiving warfarin or similar agents. Decreased AUC w/ rifampin. Monitor for methotrexate-related toxicity in concomitant use w/ & etoricoxib >90 mg daily. Diminished antihypertensive effect of ACE inhibitors. Increased plasma lithium levels. Increased rate of GI ulceration & other complications w/ aspirin. Increased ethinyl estradiol conc.
ATC Classification
M01AH05 - etoricoxib ; Belongs to the class of non-steroidal antiinflammatory and antirheumatic products, coxibs.
Presentation/Packing
Form
Mexib tab 60 mg
Packing/Price
3 × 10's
Form
Mexib tab 90 mg
Packing/Price
3 × 10's
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