Mibefradil


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Angina pectoris; HTN 50 mg once daily increased if needed.
Dosage Details
Oral
Angina pectoris, Hypertension
Adult: 50 mg once daily increased if necessary.
Contraindications
Cardiac conduction disorders.
Special Precautions
Elderly.
Adverse Reactions
Abdominal pain, belching, heartburn, flushing, headache, nausea and vomiting, dizziness, lightheadedness, bradycardia, peripheral oedema, chest pain.
Drug Interactions
Potentially Fatal: Due to its CYP3A4 and CYP2D6 inhibiting effects, serious interactions have been reported with: β-blockers, diltiazem, verapamil, digitalis glycosides, atorvastatin, cerivastatin, lovastatin, simvastatin, astemizole, cisapride, terfenadine, ciclosporin, desipramine, imipramine, tacrolimus, flecainide, propafenone.
Action
Description: Mibefradil is a calcium channel blocker which acts principally on fast T-type calcium channels.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Mibefradil from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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