Miso-Fem Ortho 12

Miso-Fem Ortho 12 Mechanism of Action





Full Prescribing Info
Pharmacology: Pharmacodynamics: Misoprostol belongs to a group of hormones called prostaglandins which can cause uterine contractions and opening (ripening) of the cervix and is widely used in obstetrics and gynecology. Misoprostol also has antisecretory (inhibiting gastric acid secretions) and has mucosal protective properties. Misoprostol protects the gastro duodenal mucus by inhibiting basal, stimulated, and nocturnal acid secretion and by reducing the proteolytic activity of gastric fluid and increasing bicarbonal and mucous secretion.
Pharmacokinetics: Misoprostol is readily absorbed and undergoes de-esterification to its free acid if bound to plasma protein and its metabolites include prostaglandins-F analogues. The compound is lipophilic methyl ester prodrug and is readily metabolized to the free acid which is biologically active. When administered orally peak plasma concentration is attained within 30 minutes and rapidly declines by 120 minutes. 80% of the drug is excreted through the renal route and 15% through the fecal route.
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