Molox Drug Interactions



CCL Pharma


Full Prescribing Info
Drug Interactions
Antacids, Sucralfate, Metal Cations, Multivitamins: Oral administration of quinolones with antacids containing aluminium or magnesium, with sucralfate, with metal cations such as iron, or with multivitamins containing iron or zinc, may substantially interfere with the absorption of Quinolones. Therefore, Moxifloxacin should be taken at least 4 hours before or 8 hours after these agents.
No clinically significant drug-drug interactions between itraconazole, theophylline, warfarin, digoxin, atenolol, oral contraceptives or glyburide have been observed with Moxifloxacin. Itraconazole, theophylline, digoxin, probenecid, morphine, ranitidine, and calcium have been shown not to significantly alter the pharmacokinetics of Moxifloxacin.
Warfarin: Quinolones, including Moxifloxacin, have been reported to enhance the anticoagulant effects of warfarin or its derivatives in the patient population.
Drugs metabolized by Cytochrome P450 enzymes: In vitro studies with cytochrome P450 isoenzymes (CYP) indicate that Moxifloxacin does not inhibit CYP3A4, CYP2D6, CYP2C9, CYP2C19, or CYP1A2, suggesting that Moxifloxacin is unlikely to alter the pharmacokinetics of drugs metabolized by these enzymes.
Nonsteroidal anti-inflammatory drugs (NSAIDs): The concomitant administration of a nonsteroidal anti-inflammatory drug with a quinolone may increase the risks of CNS stimulation and convulsions.
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