The following side effects may occur: Cardiovascular: Palpitation, QT prolongation, tachycardia, vasodilation.
Central nervous system: Anxiety, chills, dizziness (2%), headache, insomnia, malaise, nervousness, pain, somnolence, tremor, vertigo.
Dermatologic: Dry skin, pruritus, rash (maculopapular, purpuric, pustular).
Endocrine & metabolic: Serum chloride increased (2%), serum ionized calcium increased (2%), serum glucose decreased (2%).
Gastrointestinal: Abdominal pain, amylase increased, amylase decreased (2%), anorexia, constipation, dry mouth, dyspepsia, flatulence, glossitis, lactic dehydrogenase increased, stomatitis, taste perversion, vomiting.
Genitourinary: Vaginal moniliasis, vaginitis.
Hematologic: Eosinophilia, leukopenia, prothrombin time prolonged, increased INR, thrombocythemia.
Increased serum levels of the following (2%): MCH, neutrophils, WBC.
Decreased serum levels of the following (2%): Basophils, eosinophils, hemoglobin, RBC, neutrophils.
Hepatic: Bilirubin decreased or increased (2%), GGTP increased, liver function test abnormal.
Neuromuscular & skeletal: Arthralgia, myalgia, weakness.
Renal: Serum albumin increased (2%).
Respiratory: Pharyngitis, pneumonia, rhinitis, sinusitis, pO2 increased (2%).
Miscellaneous: Allergic reaction, infection, diaphoresis, oral moniliasis.