Molsidomine


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Angina pectoris; Heart failure; Post-MI 1-4 mg 2-4 times/day. IV Angina pectoris; Heart failure; Post-MI 2-4 mg as a single dose; may repeat 2 mg at intervals of at least 2 hr if needed. Max: 40 mg/day.
Dosage Details
Intravenous
Angina pectoris, Heart failure, Post-myocardial infarction
Adult: 2-4 mg as a single dose; 2 mg may be repeated at intervals of at least 2 hr if necessary. Max: 40 mg daily. Infusions may be employed at a rate of up to 3 mg/hr.

Oral
Angina pectoris, Heart failure, Post-myocardial infarction
Adult: 1-4 mg 2-4 times daily.
Contraindications
Shock. Pregnancy and lactation.
Special Precautions
Hepatic insufficiency.
Adverse Reactions
Arterial hypotension, orthostatic hypotension, pruritus, rash, anorexia, nausea, headache, vertigo.
Action
Description: Molsidomine is a nitrovasodilator.
Pharmacokinetics:
Absorption: Rapidly absorbed from the GI tract. Bioavailability (oral): 44-59%. Peak plasma concentrations in 1-2 hr.
Distribution: Protein-binding of parent compound: 3-11%.
Metabolism: Hepatic; metabolised to lindidomine and other morpholine derivatives.
Excretion: Via urine. Half-life: 1-2 hr; prolonged in patients with liver cirrhosis.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Molsidomine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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