Moxisylyte


Generic Medicine Info
Indications and Dosage
Oral
Raynaud's syndrome
Adult: Initially, 40 mg 4 times daily, may be increased to 80 mg 4 times daily if necessary. In patients who are exposed to cold temperatures during the daytime: 40 mg 3 hourly during the period when symptoms are most likely to occur. If response is not achieved within 2 weeks, discontinue therapy.
Hepatic Impairment
Active liver disease: Contraindicated.
Contraindications
Active liver disease.
Special Precautions
Patient with diabetes mellitus. Elderly.
Adverse Reactions
Significant: Rarely, hepatotoxicity (including hepatitis and cholestatic jaundice).
Ear and labyrinth disorders: Vertigo.
Gastrointestinal disorders: Diarrhoea, nausea.
Nervous system disorders: Headache.
Skin and subcutaneous tissue disorders: Rash.
Vascular disorders: Facial flushing.
Overdosage
Symptom: Hypotension. Management: Put the patient in supine position until the blood pressure has been normalised.
Drug Interactions
May potentiate the effect of antihypertensive agents. Hypotensive effect may be increased by TCAs.
Action
Description: Moxisylyte is an α-adrenergic blocking agent that has vasodilating activity.
Synonym: thymoxamine.
Pharmacokinetics:
Absorption: Rapidly absorbed in the gastrointestinal tract.
Metabolism: Rapidly metabolised to desacetylmoxisylyte (metabolite I) and desmethyldesacetylmoxisylyte (metabolite II) which are both active metabolites.
Excretion: Via the kidneys. Elimination half-life: 1-2 hours.
Chemical Structure

Chemical Structure Image
Moxisylyte

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 4260, Moxisylyte. https://pubchem.ncbi.nlm.nih.gov/compound/Moxisylyte. Accessed Apr. 27, 2021.

Storage
Store below 30°C.
MIMS Class
Peripheral Vasodilators & Cerebral Activators
ATC Classification
C04AX10 - moxisylyte ; Belongs to the class of other peripheral vasodilators.
References
Anon. Moxisylyte. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 12/04/2021.

Buckingham R (ed). Moxisylyte Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/04/2021.

Joint Formulary Committee. Moxisylyte. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/04/2021.

Opilon 40 mg Tablets (Kyowa Kirin Limited). MHRA. https://products.mhra.gov.uk. Accessed 12/04/2021.

Disclaimer: This information is independently developed by MIMS based on Moxisylyte from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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