Mupirocin


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : Topical/Cutaneous Impetigo; Bacterial skin infections As 2% ointment: Apply to affected area 2-3 times/day for up to 10 days according to individual response. Secondary skin infections As 2% cream: Apply to affected area tid for up to 10 days according to individual response; re-evaluate after 3-5 days if no clinical response. Nasal Eradication of nasal colonisation with Staphylococci aureus As 2% nasal ointment: Apply into each nostril 2-3 times daily for 5-7 days.
Dosage Details
Nasal
Eradication of nasal colonisation with Staphylococci aureus
Adult: As 2% nasal ointment: Apply into each nostril 2-3 times daily for 5-7 days.
Child: Same as adult dose.
Elderly: Same as adult dose.

Topical/Cutaneous
Secondary skin infections
Adult: As 2% cream: Apply to affected area tid for up to 10 days according to individual response; re-evaluate after 3-5 days if no clinical response.
Child: ≥1 year Same as adult dose.
Elderly: Same as adult dose.

Topical/Cutaneous
Bacterial skin infections, Impetigo
Adult: As 2% ointment: Apply to affected area 2-3 times daily for up to 10 days according to individual response.
Child: Same as adult dose.
Elderly: Same as adult dose.
Contraindications
Hypersensitivity.
Special Precautions
Patient with extensive burns or open wounds. Not indicated for treatment of pressure sores. Renal impairment. Children and elderly. Pregnancy and lactation.
Adverse Reactions
Significant: Fungal or bacterial superinfection, cutaneous sensitisation reaction or severe local irritation. Rarely, systemic allergic reactions (e.g. angioedema, urticaria, generalised rash).
Eye disorders: Burning and tearing of eyes (nasal ointment).
Gastrointestinal disorders: Nausea, dry mouth (nasal ointment).
General disorders and admin site conditions: Application site reactions (e.g. localised burning, stinging or tingling sensation, localised pain and swelling), irritation, soreness.
Nervous system disorders: Headache, dysgeusia (nasal ointment).
Respiratory, thoracic and mediastinal disorders: Rhinitis, sinusitis, respiratory congestion, pharyngitis, cough, post nasal drip, nasal mucosa reactions.
Skin and subcutaneous tissue disorders: Pruritus, erythema, skin dryness, rash, contact dermatitis.
Nasal/Topical: B
Patient Counseling Information
Avoid contact with eyes and mucous membranes.
Action
Description: Mupirocin, an antibiotic produced by fermentation of Pseudomonas fluorescens, inhibits bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl transfer-ribonucleic acid (tRNA) synthetase. It has bacteriostatic effects at minimum inhibitory concentrations and bactericidal effects at higher concentrations.
Pharmacokinetics:
Absorption: Minimally absorbed systemically through intact skin.
Distribution: Plasma protein binding: >97%.
Metabolism: Rapidly metabolised to its inactive metabolite, monic acid.
Excretion: Via urine (as inactive monic acid metabolite). Elimination half-life: 17-36 minutes.
Chemical Structure

Chemical Structure Image
Mupirocin

Source: National Center for Biotechnology Information. PubChem Database. Mupirocin, CID=446596, https://pubchem.ncbi.nlm.nih.gov/compound/Mupirocin (accessed on Jan. 23, 2020)

Storage
Store below 25°C. Do not refrigerate or freeze.
MIMS Class
ATC Classification
R01AX06 - mupirocin ; Belongs to the class of other nasal preparations for topical use.
D06AX09 - mupirocin ; Belongs to the class of other topical antibiotics used in the treatment of dermatological diseases.
References
Anon. Mupirocin (Topical) . AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 09/08/2019.

Anon. Mupirocin. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 09/08/2019.

Buckingham R (ed). Mupirocin. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 09/08/2019.

Joint Formulary Committee. Mupirocin. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 09/08/2019.

Medicianz Healthcare Limited. Mupirocin Ointment 2% w/w Tube data sheet 28 June 2018. Medsafe. http://www.medsafe.govt.nz/. Accessed 09/08/2019.

Mupirocin Cream (Glenmark Pharmaceuticals Inc., USA). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 09/08/2019.

Mupirocin Ointment (Glenmark Pharmaceuticals Inc., USA). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 13/10/2015.

Disclaimer: This information is independently developed by MIMS based on Mupirocin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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