Natamycin


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : Ophthalmic Fungal keratitis As 5% ophthalmic susp: Instill 1 drop into the conjunctival sac of the affected eye(s) 1-2 hourly, reduce to 1 drop 6-8 times daily after 3-4 days.  Duration of treatment: 2-3 weeks. Gradually reduce dose at 4-7 day intervals. Fungal blepharitis; Fungal conjunctivitis As 5% ophthalmic susp: Instill 1 drop into the conjunctival sac of the affected eye(s) 4-6 times daily.
Dosage Details
Ophthalmic
Fungal keratitis
Adult: As 5% ophthalmic susp: Instill 1 drop into the conjunctival sac of the affected eye(s) 1-2 hourly, reduce to 1 drop 6-8 times daily after 3-4 days. Duration of treatment: 2-3 weeks. Gradually reduce dose at 4-7 day intervals.

Ophthalmic
Fungal blepharitis, Fungal conjunctivitis
Adult: As 5% ophthalmic susp: Instill 1 drop into the conjunctival sac of the affected eye(s) 4-6 times daily.
Contraindications
Hypersensitivity.
Special Precautions
Patient with epithelial ulceration. Pregnancy and lactation.
Adverse Reactions
Cardiac disorders: Chest pain.
Eye disorders: Changes in vision, corneal opacity; eye discomfort, oedema, hyperaemia, irritation, pain, foreign body sensation, paraesthesia, tearing.
Immune system disorders: Allergic reaction.
Respiratory, thoracic and mediastinal disorders: Dyspnoea.
Patient Counseling Information
Avoid use of contact lenses during treatment.
MonitoringParameters
Assess for treatment effectiveness; if no improvement after 7-10 days, re-evaluate therapy.
Action
Description: Natamycin, a tetraene polyene antifungal antibiotic with predominantly fungicidal activity, is derived from Streptomyces natalensis. It binds to the sterol moiety of the fungal cell membrane and alters the membrane permeability, thereby allowing the depletion of essential cellular contents.
Pharmacokinetics:
Absorption: Not expected to be absorbed systemically (ophthalmic).
Distribution: Adheres onto cornea; retained in conjunctival fornices; does not produce effective intraocular fluid levels.
Chemical Structure

Chemical Structure Image
Natamycin

Source: National Center for Biotechnology Information. PubChem Database. Natamycin, CID=5284447, https://pubchem.ncbi.nlm.nih.gov/compound/Natamycin (accessed on Jan. 22, 2020)

Storage
Store between 2-24°C. Do not freeze. Protect from excessive heat and light.
ATC Classification
S01AA10 - natamycin ; Belongs to the class of antibiotics. Used in the treatment of eye infections.
References
Anon. Natamycin (EENT). AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 10/01/2020.

Anon. Natamycin. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 10/01/2020.

Buckingham R (ed). Natamycin. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. http://www.medicinescomplete.com. Accessed 10/01/2020.

Natacyn (Alcon Laboratories, Inc.). U.S. FDA. https://www.fda.gov/. Accessed 10/01/2020.

Natacyn Ophthalmic Suspension 5% Sterile (Alcon Laboratories, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 10/01/2020.

Disclaimer: This information is independently developed by MIMS based on Natamycin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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