Nicorandil


Concise Prescribing Info
Indications/Uses
Angina pectoris.
Dosage/Direction for Use
Adult : PO Initial: 10 mg bid. Dose can be increased up to 40 mg bid according to patient's response and tolerance. Max: 40 mg bid. In patients prone to headache:  Initial: 5 mg bid.
Dosage Details
Oral
Angina pectoris
Adult: Initially, 10 mg bid. Dose can be increased up to 40 mg bid according to patient's response and tolerance. Max: 40 mg bid. In patients prone to headache:  Initially, 5 mg bid.
Hepatic Impairment
Dose reduction may be necessary.
Administration
May be taken with or without food.
Contraindications
Cardiogenic shock; hypotension; left ventricular failure with low filling pressure; lactation.
Special Precautions
Hypovolaemia, low systolic BP, acute pulmonary oedema, pregnancy. May impair ability to drive or operate machinery.
Adverse Reactions
Headache (usually transitory), flushing, dizziness, nausea, vomiting and weakness. Hypotension and reflex tachycardia at high doses.
Drug Interactions
Hypotensive interaction may occur with alcohol, TCAs, antihypertensives and other vasodilators.
Potentially Fatal: Enhanced hypotensive effect with sildenafil and other phosphodiesterase type-5 inhibitors.
Action
Description: Nicorandil dilates arterioles and large coronary arteries by opening the potassium channels, and stimulates guanylate cyclase causing venous vasodilatation. It therefore reduces preload and afterload, and improves coronary blood flow.
Pharmacokinetics:
Absorption: Absorbed well from the GI tract (oral); peak plasma concentrations after 30-60 min.
Distribution: Protein-binding: Slightly bound.
Metabolism: Denitration.
Excretion: Via urine (as metabolites); 1 hr (elimination half-life).
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Nicorandil from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
  • Nicoril
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