Nicotinamide


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Treatment of nicotinic acid deficiency 100-300 mg/day in divided doses. Topical Mild to moderate inflammatory acne As 4% gel: Apply bid. Reduce frequency if excessive dryness, irritation or peeling occurs.
Dosage Details
Oral
Treatment of nicotinic acid deficiency
Adult: 100-300 mg daily in divided doses.
Child: ≥12 yr Same as adult dose.

Topical/Cutaneous
Mild to moderate inflammatory acne
Adult: As a 4% gel: Apply bid, reduce to once daily or on alternate days if excessive dryness, irritation or peeling occurs.
Child: Same as adult dose.
Incompatibility
Incompatible with alkalis and strong acids.
Special Precautions
Patient with hepatic disease, peptic ulcer. Children. Pregnancy and lactation.
Adverse Reactions
Significant: Dry skin (topical).
Hepatic: Rarely, abnormal LFT, jaundice, chronic hepatic damage.
Haematologic: Rarely, abnormal prothrombin time, hypoalbuminaemia.
Dermatologic: Irritation, pruritus, erythema, burning sensation (topical).
Patient Counseling Information
Avoid contact with eyes or mucous membranes (topical).
MonitoringParameters
Periodically monitor hepatic function and blood glucose levels.
Drug Interactions
May increase the adverse effect of HMG-CoA reductase inhibitors.
Lab Interference
May cause false increase of urinary catecholamines in some fluorometric determinations.
Action
Description: Nicotinamide is a vitamin B3 derivative. It is incorporated into coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are involved in multiple cellular metabolic pathways (e.g. tissue respiration, lipid metabolism and glycogenolysis). It also has significant anti-inflammatory activity.
Pharmacokinetics:
Absorption: Readily absorbed from the GI tract. Time to peak plasma concentration: 20-70 minutes.
Distribution: Widely distributed in the body tissues. Enters breast milk.
Metabolism: Metabolised in the liver to N-methylnicotinamide, 2-pyridone and 4-pyridone derivatives and nicotinuric acid.
Excretion: Via urine (as unchanged drug and as metabolites). Elimination half-life: 45 minutes.
Chemical Structure

Chemical Structure Image
Nicotinamide

Source: National Center for Biotechnology Information. PubChem Database. Nicotinamide, CID=936, https://pubchem.ncbi.nlm.nih.gov/compound/Nicotinamide (accessed on Jan. 22, 2020)

Storage
Store at or below 25°C.
ATC Classification
A11HA01 - nicotinamide ; Belongs to the class of other plain vitamin preparations. Used as dietary supplements.
References
Anon. Niacinamide. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 14/08/2017.

Joint Formulary Committee. Nicotinamide. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 14/08/2017.

McEvoy GK, Snow EK, Miller J et al (eds). Niacin, Niacinamide. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 14/08/2017.

Nicotinamide Tablets 100 mg (Nutrition Warehouse Limited). MHRA. https://products.mhra.gov.uk/. Accessed 14/08/2017.

Disclaimer: This information is independently developed by MIMS based on Nicotinamide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in