Nifurtoinol


Concise Prescribing Info
Indications/Uses
UTI.
Dosage/Direction for Use
Adult : PO Up to 300 mg/day in divided doses.
Dosage Details
Oral
Urinary tract infections
Adult: Up to 300 mg daily in divided doses.
Contraindications
Hypersensitivity to nitrofurans; impaired renal function; infants <3 mth; G6PD deficiency; porphyria; pregnancy.
Special Precautions
Elderly; preexisting pulmonary, hepatic, neurological dysfunction; conditions which may predispose to peripheral neuropathy (anaemia; DM; electrolyte imbalance; vit B and folate deficiency), lactation.
Adverse Reactions
GI effects; neurological effects; severe, sometimes irreversible peripheral polyneuropathy; hypersensitivity reactions; acute pulmonary sensitivity; subacute or chronic pulmonary symptoms; hepatotoxicity; blood disorders; brownish discolouration of urine.
Drug Interactions
Quinolone antibacterials may antagonise effects; antibacterial effects may be decreased by carbonic anhydrase inhibitors and drugs that alkalinise the urine. Probenecid or sulfinpyrazone may reduce excretion of nifurtoinol; magnesium trisilicate may reduce absorption. May reduce the effects of oral contraceptives.
Action
Description: Nifurtoinol has properties similar to nitrofurantoin. It is bactericidal to most gram positive and gram negative urinary tract pathogens.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Nifurtoinol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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