Nimorazole


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Trichomoniasis 2 g as a single dose. Sexual partners should be treated concomitantly. Amoebiasis 1 g twice daily for 5-10 days. Giardiasis 500 mg twice daily for 5-7 days. Acute ulcerative gingivitis 500 mg twice daily for 2 days.
Dosage Details
Oral
Amoebiasis
Adult: 1 g bid for 5-10 days.

Oral
Giardiasis
Adult: 500 mg bid for 5-7 days.

Oral
Trichomoniasis
Adult: 2 g as a single dose. Alternatively, 1 g every 12 hr for 3 doses or 250 mg tid for 5-7 days. Sexual partners should be treated concomitantly.

Oral
Acute ulcerative gingivitis
Adult: 500 mg bid for 2 days.
Contraindications
Pregnancy and lactation.
Special Precautions
Blood dyscrasias; active disease of the CNS.
Adverse Reactions
Nausea, vomiting, diarrhoea, anorexia, epigastric pain, vertigo, somnolence, rash, pruritus.
Drug Interactions
Disulfiram-like reaction may occur with alcohol.
Action
Description: Nimorazole is an antimicrobial with activity against anaerobic bacteria and protozoa. Its actions and properties are similar to metronidazole.
Pharmacokinetics:
Absorption: Readily absorbed from the GI tract. Peak plasma levels within 2 hr.
Distribution: High levels reported to occur in salivary and vaginal secretions; distributes in breast milk.
Excretion: Via urine (as unchanged drug and 2 active metabolites).
Disclaimer: This information is independently developed by MIMS based on Nimorazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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