Nitazoxanide


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Cryptosporidiosis; Giardiasis 500 mg 12 hourly for 3 days.
Dosage Details
Oral
Cryptosporidiosis, Giardiasis
Adult: 500 mg 12 hourly for 3 days.
Child: 1-3 years 100 mg 12 hourly; 4-11 years 200 mg 12 hourly for 3 days. >12 years Same as adult dose. All doses to be taken for 3 days.
Administration
Should be taken with food.
Reconstitution
Oral suspension: Reconstitute with 48 mL of water.
Contraindications
Hypersensitivity.
Special Precautions
Patient with HIV and immunodeficiency. Pregnancy and lactation.
Adverse Reactions
Gastrointestinal disorders: Nausea, vomiting, abdominal pain, diarrhoea, gastroesophageal reflux disease.
Nervous system disorders: Headache, dizziness.
Renal and urinary disorders: Chromaturia.
Respiratory, thoracic and mediastinal disorders: Dyspnoea.
Skin and subcutaneous tissue disorders: Skin rash, urticaria.
Food Interaction
Increased AUC with food.
Action
Description: Nitazoxanide is an antiprotozoal agent which impairs the anaerobic metabolism of susceptible organisms via the interference of the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction. In vitro, it inhibits the growth of sporozoites and oocysts of Cryptosporidium parvum and the trophozoites of Giardia lamblia.
Pharmacokinetics:
Absorption: Absorbed from the gastrointestinal tract. Time to peak plasma concentration: 1-4 hours (as tizoxanide and tizoxanide glucuronide).
Distribution: Plasma protein binding: > 99% (tizoxanide).
Metabolism: Rapidly hydrolysed to tizoxanide (active desacetyl metabolite) which partially undergoes further conjugation, primarily by glucuronidation.
Excretion: Via faeces (approx 67%) and urine (approx 33%). Elimination half-life: 1-1.6 hours (tizoxanide).
Chemical Structure

Chemical Structure Image
Nitazoxanide

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 41684, Nitazoxanide. https://pubchem.ncbi.nlm.nih.gov/compound/Nitazoxanide. Accessed Oct. 26, 2020.

Storage
Store at 25°C.
MIMS Class
ATC Classification
P01AX11 - nitazoxanide ; Belongs to the class of other agents used in the treatment amoebiasis and other protozoal diseases.
References
Alinia Tablet and Powder, for Suspension (Romark Laboratories, L.C.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 22/09/2020.

Anon. Nitazoxanide. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 22/09/2020.

Anon. Nitazoxanide. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 22/09/2020.

Buckingham R (ed). Nitazoxanide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 22/09/2020.

Nitazoxanide. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com/. Accessed 22/09/2020.

Disclaimer: This information is independently developed by MIMS based on Nitazoxanide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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