Nitrendipine


Concise Prescribing Info
Indications/Uses
HTN.
Dosage/Direction for Use
Adult : PO 20 mg/day in 1 or 2 divided doses. Max: 20 mg bid.
Dosage Details
Oral
Hypertension
Adult: 20 mg daily as a single dose or in 2 divided doses, may be increased to 20 mg bid as necessary to control resistant HTN.
Elderly: Initially, 10 mg daily.
Hepatic Impairment
Initially, 5-10 mg once daily.
Administration
Should be taken with food.
Contraindications
Unstable angina pectoris, use w/in 1 mth of MI, cardiogenic shock.
Special Precautions
Patients w/ severe aortic stenosis, poor cardiac reserve, heart failure. Hepatic impairment. Elderly. Pregnancy and lactation.
Adverse Reactions
Headache, fatigue, flushing, palpitations, dizziness, peripheral oedema, polyuria, elevated LFTs.
Drug Interactions
Increased serum levels w/ cimetidine. Decreased serum levels w/ bile acids (e.g. ursodeoxycholic acid).
Food Interaction
May increase serum concentration w/ grapefruit juice.
Action
Description: Nitrendipine relaxes coronary vascular smooth muscles by inhibiting Ca ions. It lowers BP primarily by arteriolar dilation.
Pharmacokinetics:
Absorption: Well absorbed from the GI tract. Absolute bioavailability: 10-30%. Time to peak plasma concentration: 1-3 hr.
Distribution: Plasma protein binding: Approx 98%.
Metabolism: Metabolised in the liver. Undergoes extensive first-pass metabolism.
Excretion: Via urine and faeces (as inactive metabolites, <0.1% as unchanged drug). Terminal elimination half-life: Approx 10-22 hr.
Storage
Protect from light.
MIMS Class
References
Anon. Nitrendipine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 17/12/2013.

Buckingham R (ed). Nitrendipine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 17/12/2013.

Preston CL (ed). Calcium-channel blockers + Grapefruit juice. Stockley’s Drug Interactions [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/05/2014.

Preston CL (ed). Calcium-channel blockers + H2-receptor antagonists. Stockley’s Drug Interactions [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/05/2014.

Preston CL (ed). Calcium-channel blockers; Nitrendipine + Bile acids. Stockley’s Drug Interactions [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/05/2014.

Wickersham RM. Nitrendipine. Facts and Comparisons [online]. St. Louis, MO. Wolters Kluwer Clinical Drug Information, Inc. https://www.wolterskluwercdi.com/facts-comparisons-online/. Accessed 17/12/2013.

Disclaimer: This information is independently developed by MIMS based on Nitrendipine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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