Adult: 75 mg bid for 5 days. Initiate w/in 2 days of onset of symptoms. Child: 0-1 mth 2 mg/kg; >1-3 mth 2.5 mg/kg; >3-12 mth 3 mg/kg. >1 yr ≤15 kg: 30 mg; >15-23 kg: 45 mg; >23-40 kg: 60 mg; >40 kg: 75 mg. All doses to be given bid for 5 days. Initiate w/in 2 days of onset of symptoms.
Oral Prophylaxis of influenza A and B
Adult: 75 mg once daily for at least 10 days. Initiate w/in 2 days of exposure. For community outbreak: May continue dosing for up to 6 wk. Child: 0-1 mth 2 mg/kg; >1-3 mth 2.5 mg/kg; >3-12 mth 3 mg/kg. >1 yr ≤15 kg: 30 mg; >15-23 kg: 45 mg; >23-40 kg: 60 mg; >40 kg: 75 mg. All doses to be given once daily for 10 days. Initiate w/in 2 days of exposure. For community outbreak: May continue dosing for up to 6 wk.
Prophylaxis of influenza A and B: Haemodialysis patient: 30 mg after every 2nd dialysis session. Peritoneal dialysis patient: 30 mg once wkly.
30 mg every 2nd day.
30 mg once daily.
Influenza A and B: Haemodialysis patient: 30 mg after each dialysis session. Peritoneal dialysis patient: 30 mg as a single dose.
30 mg once daily.
30 mg bid.
May be taken with or without food. May be taken w/ meals to reduce GI discomfort. Cap may be opened & mixed w/ sweetened food products eg chocolate syr, sweetened condensed milk, apple sauce or yogurt. Swallow mixt immediately after preparation.
Reconstitute w/ 55 mL of water to a final concentration of 6 mg/mL susp.
Hypersensitivity to oseltamivir.
Patient w/ resp disease, chronic cardiac disease. Renal and severe hepatic impairment. Immunocompromised patient. Childn. Pregnancy and lactation.
Nausea, vomiting, abdominal pain, insomnia, bronchitis, vertigo, diarrhoea, cough, dizziness, headache, fatigue, unstable angina, anaemia, arrhythmias, GI bleeding, haemorrhagic or pseudomembranous colitis, pneumonia, pyrexia, peritonsillar abscess, aches and pains, upper resp infections, dyspepsia, rhinorrhoea. In childn: Vomiting and other GI disturbances, bronchitis, asthma, conjunctivitis, dermatitis, ear disorders, otitis media, epistaxis, lymphadenopathy, sinusitis, pneumonia. Potentially Fatal: Anaphylaxis and skin rashes (e.g. Stevens-Johnson syndrome, erythema multiforme, epidermal necrolysis; neuropsychiatric events (e.g. delirium, hallucinations, abnormal behaviour). Rarely, fulminant hepatitis or hepatic failure.
Monitor closely for signs and symptoms of behavioural changes.
May potentially inhibit replication of influenza virus in live/attenuated influenza virus vaccine.
Description: Oseltamivir is a prodrug of oseltamivir carboxylate. Oseltamivir carboxylate inhibits neuraminidase (sialidase), a viral surface enzyme which is responsible for the replication and infectivity of influenza virus A and B, thereby preventing the release of viruses from infected cells. Pharmacokinetics: Absorption: Readily absorbed from the GI tract. Bioavailability: 75% (as carboxylate). Time to peak plasma concentration: W/in 3-4 hr (as carboxylate). Distribution: Distributed throughout the body, including the upper and lower resp tract. Volume of distribution: 23-26 L (as carboxylate). Plasma protein binding: Approx 3% (as carboxylate); 42% (as parent drug). Metabolism: Extensively metabolised to oseltamivir carboxylate by hepatic esterases. Excretion: Via urine (>90% as carboxylate); faeces. Elimination half-life: 1-3 hr (as parent drug); 6-10 hr (as carboxylate).
Store at 25°C. Reconstituted susp: Store between 2-8°C for up to 17 days or at 25°C for up to 10 days. Do not freeze.
J05AH02 - oseltamivir ; Belongs to the class of neuraminidase inhibitors. Used in the systemic treatment of viral infections.
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