Oxytetracycline


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Susceptible infections 250-500 mg 4 times/day. Max: 4 g/day. Acne 250-500 mg twice daily. Uncomplicated gonorrhoea Initial: 1.5 g, then 0.5 g 4 times/day, up to a total of 9 g/treatment course. IM Susceptible infections 250 mg once daily. Ophth Superficial ophth infections W/ other agents: As oint: Apply 2-4 times/day. As susp: Instill 1-2 drops 3 times/day. Topical Infected dermatitis W/ topical steroid: Apply up to 4 times/day.
Dosage Details
Intramuscular
Susceptible infections
Adult: 250 mg once daily or 300 mg daily in 2-3 divided doses.
Child: >8 yr: 15-25 mg/kg (max 250 mg) daily in 2-3 divided doses.

Ophthalmic
Superficial ophthalmic infections
Adult: Used in combination with other agents: As ointment: Apply a small amount in the lower conjunctival sac of the infected eye 2-4 times daily. As suspension: Instill 1-2 drops into the affected eye tid.

Oral
Susceptible infections
Adult: 250-500 mg 4 times daily. Max 4 g daily.
Child: >8 yr: 25-50 mg/kg daily in 4 divided doses.

Oral
Acne
Adult: 250-500 mg bid.

Oral
Uncomplicated gonorrhoea
Adult: 1.5 g initially, followed by 0.5 g four times daily up to a total of 9 g per treatment course.

Topical/Cutaneous
Infected dermatitis
Adult: In combination with a topical steroid: Apply up to 4 times daily.
Renal Impairment
Intramuscular:
Dosage may need to be reduced.
Oral:
Dosage may need to be reduced.
Administration
Should be taken on an empty stomach. Take 1 hr before or 2 hr after meals.
Contraindications
Hypersensitivity to tetracyclines, children <8 yr, renal damage. Pregnancy, lactation.
Special Precautions
Elderly, renal or hepatic impairment; myasthenia gravis; lupus erythematosus, children <12 yr.
Adverse Reactions
Anorexia, nausea, vomiting,diarrhoea, glossitis, dysphagia, photosensitivity, oesphageal irritation and ulceration, nephrotoxicity, enterocolitis, rash (rare), blood dyscrasias. Headache, visual disturbances; intracranial hypertension; bulging fontanelles (infants).
Potentially Fatal: Rare. Fulminant diarrhoea in post operative patients.
Drug Interactions
Antacids, iron, aluminum, calcium, magnesium, zinc salts reduce absorption. Concurrent use may cause increased levels of lithium, digoxin, halofantrine and theophylline; decreased concentrations of atovaquone. Increased risk of ergotism with ergot alkaloids. May cause failure of oral contraception.
Potentially Fatal: Interferes with anticoagulant control. Nephrotoxic effects exacerbated by diuretics, methoxyflurane or other nephrotoxic drugs; avoid concurrent use with potentially hepatotoxic drugs. Increased incidence of benign intracranial hypertension with retinoids.
Food Interaction
Absorption reduced by food, milk and milk products. Give 1 hr before or 2 hr after meals.
Lab Interference
Interferes with urinary glucose and catecholamine estimations.
Action
Description: Oxytetracycline binds reversibly to the 30S and possibly 50S ribosomal subunits, thus inhibiting bacterial protein synthesis and arresting cell growth. It is active against a wide range of gram-positive and gram-negative organisms.
Pharmacokinetics:
Distribution: Protein-binding: 20-40%
Metabolism: Hepatic (small amounts).
Excretion: Urine, faeces; 9 hr (elimination half-life).
Disclaimer: This information is independently developed by MIMS based on Oxytetracycline from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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